Investigation of Health-Related Quality of Life Outcomes in Cancer Patients: Findings from an Observational Study Using
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MEDICINE
Investigation of Health-Related Quality of Life Outcomes in Cancer Patients: Findings from an Observational Study Using the EQ-5D in Italy Gianluigi Casadei 1 & Keith Tolley 2 & Monica Bettio 3 & Federica Bozza 4 & Alessandro Cafaro 5 & Maria C. Dall’Ara 6 & Ambra Pedrazzini 7 & Valeria Scintu 7 & Giulia Zanotti 8 & Angelo A. Bignamini 1 Accepted: 10 August 2020 / Published online: 18 August 2020 # Springer Nature Switzerland AG 2020
Abstract There is a lack of data on the general health-related quality of life (HRQoL) of cancer patients treated in Italian hospitals. The EQ5D can be used to generate a visual analogue scale score and a utility value that enable comparison of HRQoL for patients across cancer types and stages and can provide values for use in economic evaluations of anti-cancer treatments. The study collected data for 802 cancer patients receiving treatment in one of six hospitals between April 16, 2018, and September 5, 2018. Participants had a diagnosis of chronic myeloid leukaemia (CML), lung cancer, breast cancer or colon cancer, and had Italian citizenship. The average age was 63 years old (range 26–92), and 62% were female. The mean EQ-5D scores were 71.50 (SD ± 17.38) for the visual analogue scale (VAS) and 0.86 (SD ± 0.13) for the utility index value. CML patients demonstrated the highest VAS scores and utility values compared with any of the solid cancers. Patient-level utility values and VAS scores were significantly correlated (r = 0.568, p < 0.0001) and remained so when stratified by treatment line or cancer type. VAS scores significantly decreased with increasing treatment line; however, utility values remained consistent between treatment lines. The study has shown it is possible to collect clinically meaningful HRQoL data in Italian cancer patients. The mean EQ-5D scores vary between cancer type and therefore, it is important to have specific data collected to guide cost utility analyses and thereby policy-making decisions that can be generalised to the whole Italian population. Keywords EQ-5D . Cancer . Italy . Health-related quality of life . Utility values
This article is part of the Topical Collection on Medicine Electronic supplementary material The online version of this article (https://doi.org/10.1007/s42399-020-00449-z) contains supplementary material, which is available to authorized users. * Gianluigi Casadei [email protected] 1
School of Hospital Pharmacy, University of Milan, Milan, Italy
2
Tolley Health Economics Ltd, Buxton, Derbyshire, England
3
ULSS3 Serenissima, Venezia Mestre, Italy
4
Hospital Spedali Civili, Brescia, Italy
5
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (I.R.S.T.) IRCCS, Meldola (FC), Italy
6
Azienda Ospedaliero - Universitaria di Ferrara, Cona, Italy
7
Hospital G. Brotzu, Cagliari, Italy
8
Negrar di Valpolicella, IRCCS Ospedale Sacro Cuore Don Calabria, Verona, Italy
Introduction Health-related quality of life (HRQoL) data are used widely in the economic evaluation of health care interventions.
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