Joint Multi-modal Parcellation of the Human Striatum: Functions and Clinical Relevance
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ORIGINAL ARTICLE
Joint Multi-modal Parcellation of the Human Striatum: Functions and Clinical Relevance Xiaojin Liu1,2 • Simon B. Eickhoff1,2 • Felix Hoffstaedter1,2 • Sarah Genon1,2 Svenja Caspers3,4 • Kathrin Reetz6 • Imis Dogan5,6 • Claudia R. Eickhoff3,7 • Ji Chen1,2 • Julian Caspers3,8 • Niels Reuter1,2 • Christian Mathys8,9 • Andre´ Aleman10 • Renaud Jardri11 • Valentin Riedl12 • Iris E. Sommer9 • Kaustubh R. Patil1,2
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Received: 21 November 2019 / Accepted: 10 April 2020 Ó Shanghai Institutes for Biological Sciences, CAS 2020
Abstract The human striatum is essential for both lowand high-level functions and has been implicated in the pathophysiology of various prevalent disorders, including Parkinson’s disease (PD) and schizophrenia (SCZ). It is known to consist of structurally and functionally divergent subdivisions. However, previous parcellations are based on a single neuroimaging modality, leaving the extent of the multi-modal organization of the striatum unknown. Here, we investigated the organization of the striatum across Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12264-020-00543-1) contains supplementary material, which is available to authorized users.
three modalities—resting-state functional connectivity, probabilistic diffusion tractography, and structural covariance—to provide a holistic convergent view of its structure and function. We found convergent clusters in the dorsal, dorsolateral, rostral, ventral, and caudal striatum. Functional characterization revealed the anterior striatum to be mainly associated with cognitive and emotional functions, while the caudal striatum was related to action execution. Interestingly, significant structural atrophy in the rostral and ventral striatum was common to both PD and SCZ, but atrophy in the dorsolateral striatum was specifically attributable to PD. Our study revealed a cross-modal
& Kaustubh R. Patil [email protected]
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Department of Diagnostic and Interventional Radiology, Medical Faculty, University of Du¨sseldorf, 40225 Du¨sseldorf, Germany
1
Institute of Neuroscience and Medicine (INM-7, Brain and Behaviour), Research Centre Ju¨lich, Ju¨lich, Germany
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2
Institute of Systems Neuroscience, Heinrich Heine University Du¨sseldorf, Du¨sseldorf, Germany
Institute of Radiology and Neuroradiology, Evangelisches Krankenhaus, University of Oldenburg, 26129 Oldenburg, Germany
10
Department of Neuroscience, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands
11
SCALab (CNRS UMR9193) & CHU de Lille, Hoˆpital Fontan, Poˆle de Psychiatrie (CURE), Universite´ de Lille, 59037 Lille, France
12
Departments of Neuroradiology, Nuclear Medicine and Neuroimaging Center, Technische Universita¨t Mu¨nchen, 80333 Munich, Germany
3
Institute of Neuroscience and Medicine (INM-1), Research Centre Ju¨lich, 52428 Ju¨lich, Germany
4
Institute for Anatomy I, Medical Faculty, Heinrich Heine University Du¨sseldorf, 4022
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