Knowledge Discovery in Life Science Literature PAKDD 2006 Internatio

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Edited by S. Istrail, P. Pevzner, and M. Waterman Editorial Board: A. Apostolico S. Brunak M. Gelfand T. Lengauer S. Miyano G. Myers M.-F. Sagot D. Sankoff R. Shamir T. Speed M. Vingron W. Wong

Subseries of Lecture Notes in Computer Science

Eric G. Bremer Jörg Hakenberg Eui-Hong (Sam) Han Daniel Berrar Werner Dubitzky (Eds.)

Knowledge Discovery in Life Science Literature PAKDD 2006 International Workshop, KDLL 2006 Singapore, April 9, 2006 Proceedings

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Series Editors Sorin Istrail, Brown University, Providence, RI, USA Pavel Pevzner, University of California, San Diego, CA, USA Michael Waterman, University of Southern California, Los Angeles, CA, USA Volume Editors Eric G. Bremer Children’s Memorial Hospital, Brain Tumor Research Program 2300 Children’s Plaza, Chicago, Illinois 60614, USA E-mail: [email protected] Jörg Hakenberg Humbold-Universität zu Berlin Computer Science Department, Knowledge Management in Bioinformatics Unter den Linden 6, 10099 Berlin, Germany E-mail: [email protected] Eui-Hong (Sam) Han iXmatch Inc. 5555 West 78th Street Suite E, Minneapolis, MN 55439-2702, USA E-mail: [email protected] Daniel Berrar Werner Dubitzky University of Ulster School of Biomedial Sciences, Bioinformatics Research Group Cromore Road, Coleraine BT52 1SA, Northern Ireland, UK E-mail: {dp.berrar,w.dubitzky}@ulster.ac.uk Library of Congress Control Number: 2006921543 CR Subject Classification (1998): H.2.8, J.3, I.2, H.3, I.5, I.4, F.1 LNCS Sublibrary: SL 8 – Bioinformatics ISSN ISBN-10 ISBN-13

0302-9743 3-540-32809-2 Springer Berlin Heidelberg New York 978-3-540-32809-4 Springer Berlin Heidelberg New York

This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springer.com © Springer-Verlag Berlin Heidelberg 2006 Printed in Germany Typesetting: Camera-ready by author, data conversion by Scientific Publishing Services, Chennai, India Printed on acid-free paper SPIN: 11683568 06/3142 543210

Preface

This volume of the Springer Lecture Notes in Computer Science series contains the contributions presented at the International Workshop on Knowledge Discovery Life Science Literature 2006 (KDLL 2006) held in Singapore, 9 April 2006, in conjunction with the 10th Pacific-Asia Conference on Knowledge Discovery and Data Mining (PAKDD 2006). The life sciences encompass research and development in areas such as biology, pharmacology, biophysics, biochemistry, neuroscience, medicine, and environmental sciences. A common them