Long non-coding RNA SNHG15 in various cancers: a meta and bioinformatic analysis
- PDF / 2,447,423 Bytes
- 13 Pages / 595.276 x 790.866 pts Page_size
- 28 Downloads / 154 Views
RESEARCH ARTICLE
Open Access
Long non-coding RNA SNHG15 in various cancers: a meta and bioinformatic analysis Caizhi Chen, Yeqian Feng, Jingjing Wang, Ye Liang and Wen Zou*
Abstract Background: The snoRNA host gene SNHG15 produces a long non-coding RNA (lncRNA) with a short half-life and has been reported to be dysregulated in multiple cancers and has recently been found to be correlated with tumour progression. Therefore, this meta-analysis was performed to evaluate the generalised prognostic role of small nucleolar RNA host gene 15 (SNHG15) in malignancies, based on variable data from different studies. Methods: Four public databases were used to identify eligible studies. The association between prognostic indicators and clinical features was extracted and pooled to estimate the hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs). Publication bias was measured using Begg’s test and Egger’s test, and the stability of pooled results were measured using sensitivity analysis. Additionally, an online database based on The Cancer Genome Atlas (TCGA) was screened to further validate our results. Ultimately, we predicted the molecular regulation of SNHG15 based on the public databases. Results: In total, 11 studies including 1087 patients were ultimately enrolled in our meta-analysis. We found that SNHG15 overexpression was associated with worse overall survival (OS) and disease-free survival (DFS), and this was validated in the Gene Expression Profiling Interactive Analysis (GEPIA) cohort. Moreover, increased SNHG15 expression suggested advanced TNM stage and LNM, but was not associated with age, gender, or tumour size. No publication bias or instability of the results was observed. SNHG15 was significantly upregulated in seven cancers and elevated expression of SNHG15 indicated shorter OS and DFS in five malignancies based on the validation using the GEPIA cohort. Further functional prediction indicated that SNHG15 may participate in some cancer-related pathways. Conclusions: Upregulation of lncRNA SNHG15 was notably associated with worse prognosis and clinical features, suggesting that SNHG15 might serve as a novel prognostic factor in various cancers. Keywords: LncRNA SNHG15, Prognosis, Meta-analysis, Bioinformatics
Background Cancer is a severe health problem and is the leading cause of death worldwide, with annually increasing incidence and mortality rates. According to the latest statistics reported in CA cancer journals, 1,806,590 new cancer cases and 606,520 cancer deaths are expected to occur in the United States in 2020 [1]. Although * Correspondence: [email protected] Department of Oncology, The Second Xiangya Hospital of Central South University, Changsha 410000, Hunan, China
multidisciplinary treatments, such as surgery, chemotherapy, radiotherapy, targeted therapy, and immunotherapy, of malignancies have improved greatly in recent years, prognosis and early diagnosis remain extremely challenging [2]. As such, there is an urgent need to identify innovative and effective tar
Data Loading...
