Long-term apparent diffusion coefficient value changes in patients undergoing radiosurgical treatment of meningiomas
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ORIGINAL ARTICLE - BRAIN TUMORS
Long-term apparent diffusion coefficient value changes in patients undergoing radiosurgical treatment of meningiomas Jatta Berberat 1
&
Ulrich Roelcke 2 & Luca Remonda 1 & Lucia Schwyzer 2,3
Received: 11 June 2020 / Accepted: 2 September 2020 # Springer-Verlag GmbH Austria, part of Springer Nature 2020
Abstract Purpose A noninvasive method to predict the progress or treatment response of meningiomas is desirable to improve the tumor management. Studies showed that apparent diffusion coefficient (ADC) pretreatment values can predict treatment response in brain tumors. The aim of this study was to analyze changes of intratumoral ADC values in patients with meningiomas undergoing conservative or radiosurgery. Method MR images of 51 patients with diagnose of meningiomas were retrospectively reviewed. Twenty-five patients undergoing conservative or radiosurgery treatment, respectively, were included in the study. The follow-up data ranged between 1 and 10 years. Based on ROI analysis, the mean ADC values, ADC10%min, and ADC90%max were evaluated at different time points during follow-up. Results Baseline ADC values in between both groups were similar. The ADCmean values, ADC10%min, and ADC90%max within the different groups did not show any significant changes during the follow-up times in the untreated (ADCmean over 10 years period: 0.87 ± 0.05 × 10−3 mm2/s) and radiosurgically treated (ADCmean over 4 years period: 1.02 ± 0.12 × 10−3 mm2/s) group. However, statistically significant difference was observed when comparing the ADCmean and ADC90%max values of untreated with radiosurgically treated (p < 0.0001) meningiomas. Also, ADC10%min revealed statistically significant difference between the untreated and the radiosurgery group (p < 0.05). Conclusions ADC values in conservatively managed meningiomas remain stable during the follow-up. However, meningiomas undergoing radiosurgery reveal significant change of the mean ADC values over time, suggesting that ADC may reflect a change in the biological behavior of the tumor. These observations might suggest the value of ADC changes as an indicator of treatment response. Keywords Meningioma . ADC . Diffusion . Radiosurgery
Introduction Meningiomas are the most common intracranial tumors and account for up to 30% of all primary intracranial tumors in adults [21, 35]. They are typically slow-growing tumors that
This article is part of the Topical Collection on Brain Tumors * Jatta Berberat [email protected] 1
Division of Neuroradiology, Kantonsspital Aarau, Tellstrasse, CH-5001 Aarau, Switzerland
2
Brain Tumor Center, Kantonsspital Aarau, Aarau, Switzerland
3
Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland
arise from the meningothelial cells of the arachnoid. Histological grading of meningiomas is based on the current WHO classification. The majority of lesions are benign WHO grade I lesions, representing approximately 90% of cases. The histological subtypes of grade I meningiomas differ from the more aggressive
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