Long-term corticosteroid monotherapy successfully cured seronegative hepatitis B virus-associated glomerulonephritis: a
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NEPHROLOGY - LETTER TO THE EDITOR
Long‑term corticosteroid monotherapy successfully cured seronegative hepatitis B virus‑associated glomerulonephritis: a case report with an 8‑year follow‑up Yan Zhang1,2 · Sha Chen2 · Ding‑Wei Yang1 Received: 28 August 2020 / Accepted: 28 September 2020 © The Author(s) 2020
Editor, Seronegative hepatitis B virus (HBV)-associated glomerulonephritis (snHBV-GN) is defined as glomerulonephritis with the presence of HBV antigens in the renal tissue in the absence of HBV antigens and detectable HBV-DNA in the serum while excluding other secondary glomerulonephritis [1]. Currently, there are no therapeutic guidelines for snHBV-GN. We report a case of snHBV-GN recovered completely after long-term corticosteroid monotherapy. A 26-year-old female was admitted for foamy urine for 2 weeks. Physical examination showed: bilateral ankle edema, blood pressure of 125/83 mmHg, and no other abnormalities. Laboratory examination revealed massive proteinuria (4.1 g/24 h), hypoalbuminemia (27 g/L), and mild dyslipidemia, suggesting nephrotic syndrome. Based on renal biopsy results that HBsAg and HBcAg deposited below the capillary epithelium in linear patterns (Fig. 1a–d), alongside negative HBV antigens and undetectable HBV-DNA in the serum (
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