Mast Cells in Diabetes and Diabetic Wound Healing
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REVIEW
Mast Cells in Diabetes and Diabetic Wound Healing Jie Dong . Lihong Chen . Ying Zhang . Navin Jayaswal . Ikram Mezghani . Weijie Zhang . Aristidis Veves
Received: July 21, 2020 / Accepted: September 4, 2020 Ó The Author(s) 2020
ABSTRACT Mast cells (MCs) are granulated, immune cells of the myeloid lineage that are present in connective tissues. Apart from their classical role in allergies, MCs also mediate various inflammatory responses due to the nature of their secretory products. They are involved in important physiological and pathophysiological responses related to inflammation, chronic wounds, and autoimmune diseases. There are also indications that MCs are associated with diabetes and its complications. MCs and MC-derived mediators participate in all wound healing stages and are involved in the pathogenesis of non-healing, chronic diabetic foot ulcers (DFUs). More specifically, recent work has shown increased degranulation of skin MCs in human diabetes and diabetic mice, which is associated with Digital Features To view digital features for this article go to https://doi.org/10.6084/m9.figshare.12911561. J. Dong L. Chen Y. Zhang N. Jayaswal I. Mezghani W. Zhang A. Veves (&) Joslin-Beth Israel Deaconess Foot Center and The Rongxiang Xu, MD, Center for Regenerative Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA e-mail: [email protected] W. Zhang LanZhou University of Technology, 287 Langongping Road, Qilihe District, Lanzhou, Gansu, China
impaired wound healing. Furthermore, MC stabilization, either systemic or local at the skin level, improves wound healing in diabetic mice. Understanding the precise role of MCs in wound progression and healing processes can be of critical importance as it can lead to the development of new targeted therapies for diabetic foot ulceration, one of the most devastating complications of diabetes.
Keywords: Diabetes mellitus; Diabetic foot ulcer; Mast cells; Wound healing Key Summary Points This is a review paper that focuses on the role of mast cells in diabetic wound healing. Skin mast cells are degranulated in diabetes. Stabilization of the mast cells reduces degranulation and promotes wound healing in animal models. This can be a new treatment for diabetic foot ulceration.
Adv Ther
DIGITAL FEATURES This article is published with digital features to facilitate understanding of the article. To view digital features for this article go to https://doi. org/10.6084/m9.figshare.12911561.
INTRODUCTION More than 140 years have passed since Paul Ehrlich presented his doctoral thesis, ‘‘Contribution to The Theory and Practice of Histological Dyes,’’ in which mast cells (MCs) were first described [1, 2]. A wealth of knowledge has been generated since, and our perception of the role and functions of MCs in our bodies has been remodeled. From being known for their detrimental role in allergic diseases, such as food allergies, asthma, and anaphylaxis, for decades; to now recognized as crucial players in a d
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