Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery
There have been tremendous advances in understanding the cellular mechanisms involved in sepsis and contributing to the development of multiple organ dysfunction and mortality in this setting. The chapters in this book provide up-to-date insights into imp
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EDWARD ABRAHAM MERVYN SINGER
JEAN-LOUIS VINCENT SERIES EDITOR
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Update in Intensive Care and Emergency Medicine
Edited by J.-L. Vincent
E. Abraham M. Singer (Eds.)
Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery
With 48 Figures and 22 Tables
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Series Editor Prof. Jean-Louis Vincent Head, Department of Intensive Care Erasme University Hospital Route de Lennik 808, 1070 Brussels Belgium [email protected] Volume Editors Edward Abraham, MD University of Colorado Health Sciences Center Division Pulmonary & Critical Care Medicine E. Ninth Avenue 4200 80262 Denver, CO USA
Mervyn Singer, MD University College Hospital Bloomsbury Institute of Intensive Care Division Medicine Gower Street, WC1E 6BT London United Kingdom
ISSN 0933-6788 ISBN-10 3-540-30157-7 Springer Berlin Heidelberg New York ISBN-13 978-3-540-30157-8 Springer Berlin Heidelberg New York Library of Congress Control Number: 2006929196 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permissions for use must always be obtained from Springer. Violations are liable for prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springer.com © Springer-Verlag Berlin Heidelberg 2007 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Editor: Dr. Ute Heilmann, Heidelberg, Germany Desk Editor: Meike Stoeck, Heidelberg, Germany Typesetting and production: LE-TEX Jelonek, Schmidt & Vöckler GbR, Leipzig, Germany Cover design: WMX Design, Heidelberg, Germany Printed on acid-free paper 27/3100/YL – 5 4 3 2 1 0
Table of Contents
Setting the Scene . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . J.L. Vincent
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The Inflammatory Response Genetics and Severe Sepsis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . J. Texereau, V. Lemiale, J.-P. Mira Cell Signaling Pathways of the Innate Immune System During Acute Inflammation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . S.M. Opal, P.A. Cristofaro
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Early-Onset Pro-inflammatory Cytokines . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . C. Kaech, T. Calandra
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The Sign
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