Melanoma-restricted genes
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BioMed Central
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Melanoma-restricted genes Ena Wang1, Monica C Panelli1, Katia Zavaglia1, Susanna Mandruzzato2, Nan Hu3, Phil R Taylor3, Barbara Seliger4, Paola Zanovello2, Ralph S Freedman5 and Francesco M Marincola*1 Address: 1Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA, 2Department of Oncology and Surgical Sciences, Oncology Section, University of Padova, Padova, Italy, 3Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, 4Institute of Medical Immunology, Martin Luther University Halle-Wittenberg, 06112 Halle, Germany and 5Department of Gynecologic Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA Email: Ena Wang - [email protected]; Monica C Panelli - [email protected]; Katia Zavaglia - [email protected]; Susanna Mandruzzato - [email protected]; Nan Hu - [email protected]; Phil R Taylor - [email protected]; Barbara Seliger - [email protected]; Paola Zanovello - [email protected]; Ralph S Freedman - [email protected]; Francesco M Marincola* - [email protected] * Corresponding author
Published: 15 October 2004 Journal of Translational Medicine 2004, 2:34
doi:10.1186/1479-5876-2-34
Received: 16 September 2004 Accepted: 15 October 2004
This article is available from: http://www.translational-medicine.com/content/2/1/34 © 2004 Wang et al; licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Human metastatic cutaneous melanoma has gained a well deserved reputation for its immune responsiveness. The reason(s) remain(s) unknown. We attempted previously to characterize several variables that may affect the relationship between tumor and host immune cells but, taken one at the time, none yielded a convincing explanation. With explorative purposes, highthroughput technology was applied here to portray transcriptional characteristics unique to metastatic cutaneous melanoma that may or may not be relevant to its immunogenic potential. Several functional signatures could be identified descriptive of immune or other biological functions. In addition, the transcriptional profile of metastatic melanoma was compared with that of primary renal cell cancers (RCC) identifying several genes co-coordinately expressed by the two tumor types. Since RCC is another immune responsive tumor, commonalities between RCC and melanoma may help untangle the enigma of their potential immune responsiveness. This purely descriptive study provides, therefore, a map for the investigation of metastatic melanoma in future clinical trials and at the same time may invite consideration of
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