Metabolic Control
The HEP issue on Metabolic Control provides a state-of the art overview over both classical concepts and emerging areas in metabolism and associated disorders. In this context, metabolic control is highlighted at various levels of complexity ranging from
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Stephan Herzig Editor
Metabolic Control
Handbook of Experimental Pharmacology
Volume 233 Editor-in-Chief W. Rosenthal, Jena
Editorial Board J.E. Barrett, Philadelphia V. Flockerzi, Homburg M.A. Frohman, Stony Brook, NY P. Geppetti, Florence F.B. Hofmann, Mu¨nchen M.C. Michel, Ingelheim C.P. Page, London A.M. Thorburn, Aurora, CO K. Wang, Beijing
More information about this series at http://www.springer.com/series/164
Stephan Herzig Editor
Metabolic Control
Editor Stephan Herzig Institute for Diabetes and Cancer IDC Helmholtz Center Munich Neuherberg, Germany Joint Heidelberg-IDC Translational Diabetes Program Heidelberg University Hospital Germany
ISSN 0171-2004 ISSN 1865-0325 (electronic) Handbook of Experimental Pharmacology ISBN 978-3-319-29804-7 ISBN 978-3-319-29806-1 (eBook) DOI 10.1007/978-3-319-29806-1 Library of Congress Control Number: 2016934711 # Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Preface
The proper control of energy homeostasis and metabolism is a prerequisite for the health of an organism. Indeed, metabolic dysfunction and the aberrant metabolic adaptation to changing environmental cues represent key features of severe disease conditions in humans, ranging from obesity, insulin resistance, and other components of the metabolic syndrome to end-stage complications in diabetes and even tumor diseases. To acknowledge the increasing importance of both systemic and cellular metabolic hubs to serve as therapeutic targets in the aforementioned disease conditions, this edition of the “Handbook of Experimental Pharmacology” is dedicated to mechanisms and mediators of metabolic control. Highly distinguished leaders in the field of metabolism research have collected and summarized the current state of the art in the field. Individual chapters cove
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