Sensory and Metabolic Control of Energy Balance
The prevalence of obesity has dramatically increased in western and westernized societies, making the disease the second leading cause of unnecessary deaths in the US. Obesity results from imbalanced metabolic regulation leading to excessive lipid storage
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Series Editors Dietmar Richter, Henri Tiedge
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Wolfgang Meyerhof Hans-Georg Joost
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Ulrike Beisiegel
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Editors
Sensory and Metabolic Control of Energy Balance
Editors Wolfgang Meyerhof Department of Molecular Genetics German Institute of Human Nutrition Arthur-Scheunert-Allee 114-116 14558 Nuthetal Germany [email protected]
Ulrike Beisiegel Institute for Molecular Cell Biology University Medical Center HamburgEppendorf (UKE) University of Hamburg Martinistrasse 52 20246 Hamburg, Germany [email protected]
Hans-Georg Joost Department of Pharmacology German Institute of Human Nutrition Arthur-Scheunert-Allee 114-116 14558 Nuthetal Germany [email protected] Series Editors Dietmar Richter Center for Molecular Neurobiology University Medical Center HamburgEppendorf (UKE) University of Hamburg Martinistrasse 52 20246 Hamburg Germany [email protected]
Henri Tiedge The Robert F. Furchgott Center for Neural and Behavioral Science Department of Physiology and Pharmacology Department of Neurology SUNY Health Science Center at Brooklyn Brooklyn, New York 11203 USA [email protected]
ISBN 978-3-642-14425-7 e-ISBN 978-3-642-14426-4 DOI 10.1007/978-3-642-14426-4 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2010936507 # Springer-Verlag Berlin Heidelberg 2010 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Cover design: WMXDesign GmbH, Heidelberg, Germany Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
During the last two decades, the prevalence of obesity has dramatically increased in western and westernized societies. Its devastating health consequences include hypertension, cardiovascular diseases, or diabetes and make obesity the second leading cause of unnecessary deaths in the USA. As a consequence, obesity has a strong negative impact on the public health care systems. Recently emerging scientific insight has helped understanding obesity as a complex chronic disease with multiple causes. A multileveled gene–environment interaction appears to involve a substantial number of susceptibility genes, as well as associations with low physical activity levels and intake of high-calorie, low-cost, foods. Unfortunately, therap
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