Methadone
- PDF / 141,252 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 100 Downloads / 185 Views
1
S
Long QT syndrome: case report A man developed long QT syndrome while receiving methadone for opiate dependence. The man, who had a history of hepatitis C-related liver disease and prior IV heroin use, underwent dual chamber implantable cardioverter defibrillator (ICD) insertion for methadone-associated QT interval prolongation and torsades de pointes [dosage not clearly stated; route and duration of treatment to reaction onset not stated]. Attempts to change to an alternative agent were unsuccessful, and the man’s methadone dosage was eventually titrated from 100 to 60mg daily. He continued to experience episodes of torsades de pointes and received two discharges from his ICD. Following presentation with bacteraemia 4 years after implantation, at the age of 57 years, the cardiac device was explanted. His methadone dosage was reduced by 10mg every 48 hours to a dosage of 10mg daily. He subsequently underwent left cardiac sympathetic denervation. At last observation, his QTc remained normal, and he was being maintained on methadone 10mg daily without any episodes of syncope or presyncope. Miller MA, et al. Left cardiac sympathetic denervation for the treatment of methadone-induced long QT syndrome. Heart Rhythm 8: 1955-1957, No. 12, Dec 2011. Available from: URL: http://dx.doi.org/10.1016/j.hrthm.2011.07.023 803066786 USA
0114-9954/10/1388-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Reactions 11 Feb 2012 No. 1388
Data Loading...
