Microfluidic Very Large Scale Integration (VLSI) Modeling, Simulatio

This book presents the state-of-the-art techniques for the modeling, simulation, testing, compilation and physical synthesis of mVLSI biochips.  The authors describe a top-down modeling and synthesis methodology for the mVLSI biochips, inspired by mi

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ofluidic Very Large Scale Integration (VLSI) Modeling, Simulation, Testing, Compilation and Physical Synthesis

Microfluidic Very Large Scale Integration (VLSI)

Paul Pop Wajid Hassan Minhass Jan Madsen •

Microfluidic Very Large Scale Integration (VLSI) Modeling, Simulation, Testing, Compilation and Physical Synthesis

123

Jan Madsen Technical University of Denmark Kongens Lyngby Denmark

Paul Pop Technical University of Denmark Kongens Lyngby Denmark Wajid Hassan Minhass Technical University of Denmark Kongens Lyngby Denmark

ISBN 978-3-319-29597-8 DOI 10.1007/978-3-319-29599-2

ISBN 978-3-319-29599-2

(eBook)

Library of Congress Control Number: 2016930268 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by SpringerNature The registered company is Springer International Publishing AG Switzerland

Contents

1

Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.1 Microfluidic Biochips . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.2 mVLSI Technology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.2.1 Application Areas. . . . . . . . . . . . . . . . . . . . . . . . . 1.2.2 Motivation for Automated Physical Design and Testing Techniques. . . . . . . . . . . . . . . . . . . . . . . . 1.2.3 Motivation for Programming and Control of mVLSI Biochips . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.3 Overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Part I

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6

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8 8 10

Preliminaries

2

Design Methodology for Flow-Based Microfluidic Biochips. 2.1 Modeling and Simulation . . . . . . . . . . . . . . . . . . . . . 2.2 Physical Design and Testing . . . . . . . . . . . . . . . . . . . 2.3 Programming and Control . . . . . . . . . . . . . .