MicroRNAs in the Spinal Microglia Serve Critical Roles in Neuropathic Pain
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MicroRNAs in the Spinal Microglia Serve Critical Roles in Neuropathic Pain Simin Tang 2,3
&
Huan Jing 2,4 & Fuhu Song 1 & Haicheng Huang 1 & Wenjun Li 1 & Guiling Xie 1 & Jun Zhou 1
Received: 22 May 2020 / Accepted: 26 August 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Neuropathic pain (NP) can occur after peripheral nerve injury (PNI), and it can be converted into a maladaptive, detrimental phenotype that causes a long-term state of pain hypersensitivity. In the last decade, the discovery that dysfunctional microglia evoke pain, called “microgliopathic pain,” has challenged traditional neuronal views of “pain” and has been extensively explored. Recent studies have shown that microRNAs (miRNAs) can act as activators or inhibitors of spinal microglia in NP conditions. We first briefly review spinal microglial activation in NP. We then comprehensively describe miRNA expression changes and their potential mechanisms in the response of microglia to nerve injury. We summarize the roles of the following two representative miRNAs: miR-124, which reverses NP by keeping microglia quiescent, and miR-155, which promotes NP following microglial activation. Finally, we focused on the therapeutic potential of microglial miRNAs in NP. The findings we summarized may be essential tools for basic research and clinical treatment of NP. Keywords Neuropathic pain . MicroRNA . Microglia . Peripheral nerve injury
Abbreviations NP PNI MiRNAs DRG CNS 3′-UTRs CR3 CD11b Iba-1 POD
Neuropathic pain Peripheral nerve injury MicroRNAs Dorsal root ganglion Central nervous system 3′-Untranslated regions Complement receptor 3 Cluster of differentiation 11b Ionized calcium-binding adaptor molecule 1 Postoperative day
SNL SNT SCI CCI TLR HDLs SOCS1 NOX2 TNF p38 MAPKs
* Jun Zhou [email protected] Simin Tang [email protected]
Spinal nerve ligation Sciatic nerve transection Spinal cord injury Chronic constriction injury Toll-like recepto High-density lipoprotein Suppressor of cytokine signaling 1 NADPH oxidase Tumor necrosis factor Phosphotyrosine 38 mitogen-activated protein kinases
Guiling Xie [email protected] 1
Department of Anesthesiology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510000, Guangdong Province, People’s Republic of China
2
Department of Anesthesiology, The First People’s Hospital of Foshan, Foshan 528000, Guangdong Province, People’s Republic of China
Haicheng Huang [email protected]
3
Sun Yat-sen University, Guangzhou 510000, Guangdong Province, People’s Republic of China
Wenjun Li [email protected]
4
ZunYi Medical University, ZunYi 563100, Guizhou Province, People’s Republic of China
Huan Jing [email protected] Fuhu Song [email protected]
Mol Neurobiol
Background Neuropathic pain (NP) often results from peripheral nerve injury (PNI) in patients with diabetic neuropathy, HIV neuropathy, post-herpetic neuralgia, drug-induced neuropathy, and traumatic nerve injury. This type of pain is so severe that even a slight touch can be intensely painful a
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