MTNR1B gene on susceptibility to gestational diabetes mellitus: a two-stage hospital-based study in Southern China
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ORIGINAL ARTICLE
MTNR1B gene on susceptibility to gestational diabetes mellitus: a two‑stage hospital‑based study in Southern China Yulong Jia1 · Yi Shen1 · Xiuying Shi1 · Xuefeng Gu2 · Peng Zhang3 · Yuanlin Liu4 · Aiyong Zhu5 · Liying Jiang6,2 Received: 25 March 2020 / Accepted: 1 July 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Large-scale studies on genetic risk loci for melatonin receptor 1B (MTNR1B) gene and GDM risk have not been well generalized to the Chinese population. In this study, we performed two-stage case–control study: 1.429 pregnant women: 753 GDM/676 controls in the Southern Chinese population by genotyping 5 SNPs (rs10830963, rs1387153, rs2166706, rs1447352, and rs4753426) in MTNR1B. Genotypes were determined using the Sequenom MassARRAY platform and TaqMan allelic discrimination assay. Interactions between genetic variants and age/BMI as predictors of GDM risk were evaluated under the logistic regression model. In the first stage, the SNP rs10830963 was discovered to be potentially related to GDM risk (additive model: OR = 1.27, 95%CI = 1.05–1.55, P = 0.025), which was further confirmed in the second stage with a similar effect (additive model: OR = 1.53, 95%CI = 1.19–1.98, P = 0.005). In the combined stage, the G allele of rs10830963 was potentially associated with GDM risk (additive model: OR = 1.36, 95%CI = 1.17–1.59, P
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