Myocardial fibrosis quantified by the extracellular extravascular volume fraction is associated with the left ventricula
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Myocardial fibrosis quantified by the extracellular extravascular volume fraction is associated with the left ventricular sphericity index and the left atrial volume index Diego Moguillansky1,2*, Timothy C Wong1, Christopher G Meier1, Stephen M Testa1, David Testa1, William J Ceyrolles1, Kayla Piehler1, Peter Kellman3, Erik B Schelbert1 From 15th Annual SCMR Scientific Sessions Orlando, FL, USA. 2-5 February 2012 Summary The objective of this study is to test the hypothesis that quantitative measures of myocardial fibrosis such as the myocardial extravascular extracellular volume fraction (Ve) are associated with markers of adverse cardiac remodeling such as the left atrial volume index (LAVi) and left ventricular sphericity index (Si).
either view, and Si =EDV/[LAX^3 π /6), where EDV is the end-diastolic volume measured from short axis stacks and LAX^3 is the cube of the long axis diastolic dimension from a 4 chamber view. Multivariable linear regression models quantified the association of Ve with LAVi and Si, adjusting for key characteristics identified by stepwise selection.
Background LAVi and Si are intermediate phenotypes that precede adverse outcomes. Myocardial fibrosis is quantifiable with contemporary CMR techniques, is treatable, and may represent a therapeutic target when these intermediate phenotypes are present.
Results Ve was associated with LAVi (t value 4.5, p
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