Nanopores Sensing and Fundamental Biological Interactions
Nanopores: Sensing and Fundamental Biological Interactions examines the emerging research directions surrounding nanopores such as genome sequencing and early disease detection using biomarker identification. Nanopores are nanometer scale holes formed nat
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Samir M. Iqbal
l
Rashid Bashir
Editors
Nanopores Sensing and Fundamental Biological Interactions
Editors Samir M. Iqbal Department of Electrical Engineering Nanotechnology Research and Teaching Facility Joint Graduate Studies Committee of the Bioengineering Program University of Texas at Arlington and University of Texas Southwestern Medical Center at Dallas TX 76019, USA [email protected]
Rashid Bashir Department of Electrical and Computer Engineering Department of Bioengineering Micro and Nanotechnology Lab University of Illinois at Urbana-Champaign Champaign, IL 61820, USA [email protected]
ISBN 978-1-4419-8251-3 e-ISBN 978-1-4419-8252-0 DOI 10.1007/978-1-4419-8252-0 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011929039 # Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Dear Colleagues, We are delighted to present this book to you, which is a compilation of knowledge from leaders and experts in the field of nanopore sensors. We believe that this book will provide a good source of review articles for researchers and graduate students interested and working in the general areas of nanobiotechnology and especially on nanopore sensors. Over the years, nanopores have rightly emerged as promising tools in three areas of scientific investigations and applications. Firstly, these sensors have been used to study interesting biophysics at the single molecule level and these studies have provided useful insights into mechanisms like folding/unfolding of DNA molecules, unzipping of double-stranded DNA, examination of single molecule DNA-protein interactions, and elegant force spectroscopy measurements of biomolecule, all utilizing electronic or optical means. Secondly, these single molecule sensors can potentially be used in applications which could be loosely termed as ‘early diagnostics’, such as detection of important attributes of individual biomolecules such as methylation, identification of specific short strands such as miRNA, and discriminating molecules of different lengths, etc. And thirdly, nanopores sensors can provide a path towards the holy grail of direct sequencing of single molecules of DNA. And certainly, tremendous strides have been made towa
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