Neonates with Culture Proven Sepsis Have Lower Amounts and Percentage of CD45RA+ T Cells

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Neonates with Culture Proven Sepsis Have Lower Amounts and Percentage of CD45RA+ T Cells A. Denizmen Aygun,1,3 A. Nese Citak Kurt,1 Ahmet Godekmerdan,2 Abdullah Kurt,1 Saadet Akarsu,1 M. Kaya Gurgoze,1 and Erdal Yilmaz1

Abstract—To evaluate the expression of lymphocyte subsets in newborns diagnosed as culture proven or culture negative sepsis and to investigate the differentiation. The aim of this study is to explore neonatal immunology in newborns diagnosed as culture proven or culture negative neonatal sepsis and to identify their place in the diagnosis. This prospective study was performed in newborns who were diagnosed as neonatal sepsis and hospitalized in a tertiary care hospital and who were classified as culture proven sepsis (n=12), as culture negative sepsis (n=21) and healthy (n= 17). Lymphocyte subsets were obtained at time of diagnosis. Culture proven sepsis had statistically significant increase of WBC compared to culture negative sepsis and control groups (p

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