Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neurona

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Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection Gretchen Hermes1,2, James W Ajioka3, Krystyna A Kelly3, Ernest Mui1, Fiona Roberts4, Kristen Kasza5, Thomas Mayr3, Michael J Kirisits1,2, Robert Wollmann6, David JP Ferguson7, Craig W Roberts8, JongHee Hwang9, Toria Trendler1,2, Richard P Kennan9, Yasuhiro Suzuki10, Catherine Reardon3, William F Hickey11, Lieping Chen12 and Rima McLeod*1,2,13 Address: 1Department of Ophthalmology, University of Chicago, Chicago, IL, USA, 2Committee on Immunology, University of Chicago, Chicago, IL, USA, 3Department of Pathology, Cambridge University, Cambridge, UK, 4University Department of Pathology, Western Infirmary, Glasgow, UK, 5Department of Health Studies, The University of Chicago, Chicago, IL, USA, 6Department of Pathology, University of Chicago, Chicago, IL, USA, 7Nuffield Department of Pathology, Oxford University, Oxford, UK, 8Department of Immunology, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK, 9Albert Einstein College of Medicine, Bronx, NY, USA, 10Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute & State University, Blacksburg, VA, USA, 11Department of Pathology, Dartmouth University School of Medicine, Hanover, NH, USA, 12Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA and 13Department Pediatrics (Infectious Diseases); Committees on Molecular Medicine, Genetics, and The College, University of Chicago, Chicago, IL, USA Email: Gretchen Hermes - [email protected]; James W Ajioka - [email protected]; Krystyna A Kelly - [email protected]; Ernest Mui - [email protected]; Fiona Roberts - [email protected]; Kristen Kasza - [email protected]; Thomas Mayr - [email protected]; Michael J Kirisits - [email protected]; Robert Wollmann - [email protected]; David JP Ferguson - [email protected]; Craig W Roberts - [email protected]; Jong-Hee Hwang - [email protected]; Toria Trendler - [email protected]; Richard P Kennan - [email protected]; Yasuhiro Suzuki - [email protected]; Catherine Reardon - [email protected]; William F Hickey - [email protected]; Lieping Chen - [email protected]; Rima McLeod* - [email protected] * Corresponding author

Published: 23 October 2008 Journal of Neuroinflammation 2008, 5:48

doi:10.1186/1742-2094-5-48

Received: 17 July 2008 Accepted: 23 October 2008

This article is available from: http://www.jneuroinflammation.com/content/5/1/48 © 2008 Hermes et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any