Neurotrophin signalling in amygdala-dependent cued fear learning
- PDF / 712,584 Bytes
- 12 Pages / 595.276 x 790.866 pts Page_size
- 53 Downloads / 176 Views
REVIEW
Neurotrophin signalling in amygdala-dependent cued fear learning Susanne Meis 1,2
&
Thomas Endres 1 & Volkmar Lessmann 1,2
Received: 22 May 2020 / Accepted: 13 July 2020 # The Author(s) 2020
Abstract The amygdala is a central hub for fear learning assessed by Pavlovian fear conditioning. Indeed, the prevailing hypothesis that learning and memory are mediated by changes in synaptic strength was shown most convincingly at thalamic and cortical afferents to the lateral amygdala. The neurotrophin brain-derived neurotrophic factor (BDNF) is known to regulate synaptic plasticity and memory formation in many areas of the mammalian brain including the amygdala, where BDNF signalling via tropomyosin-related kinase B (TrkB) receptors is prominently involved in fear learning. This review updates the current understanding of BDNF/TrkB signalling in the amygdala related to fear learning and extinction. In addition, actions of proBDNF/ p75NTR and NGF/TrkA as well as NT-3/TrkC signalling in the amygdala are introduced. Keywords Amygdala . LTP . Fear . Extinction . BDNF . GABA
Abbreviations 7,8-DHF 7,8-Dihydroxyflavone ACC Anterior cingulate cortex BA Basal amygdala BDNF Brain-derived neurotrophic factor BLA Basolateral amygdala CaMKIV Calcium/calmodulin-dependent kinase IV CE Central amygdala CEl Lateral central amygdala CEm Medial central amygdala CREB cAMP response element–binding protein CS Conditioned stimulus GABA Gamma-aminobutyric acid LA Lateral amygdala LTP Long-term potentiation MAPK Mitogen-activated protein kinase MGm Medial geniculate body mPFC Medial prefrontal cortex NT-3 Neurotrophin-3 NT-4/5 Neurotrophin-4/5
* Susanne Meis [email protected] 1
Institut für Physiologie, Medizinische Fakultät, Otto-von-Guericke-Universität, Leipziger Str. 44, 39120 Magdeburg, Germany
2
Center for Behavioral Brain Sciences, Magdeburg, Germany
PC7 PI-3 kinase PIN PLCγ PVT SG Shc Ras TrkA TrkB TrkC US
Proprotein convertase 7 Phosphatidylinositol-3 kinase Posterior intralaminar nucleus Phospholipase C gamma Paraventricular thalamic nucleus Suprageniculate nucleus Specific adaptor protein Specific small GTPase Tropomyosin-related kinase A Tropomyosin-related kinase B Tropomyosin-related kinase C Unconditioned stimulus
Introduction The amygdala is a telencephalic group of diverse, interconnected nuclei in the brain (Pitkanen et al. 1997; Knapska et al. 2007) that has been implicated in a wide variety of functions like emotion, motivation, learning and memory (Aggleton 1993; LeDoux 2000; Seymour and Dolan 2008; Pape and Pare 2010; Tye 2018). This region, located near the temporal pole of the mammalian cerebral hemisphere, is generally divided into several nuclei according to neuroanatomical and cytoarchitectural characteristics (Swanson and Petrovich 1998; Pitkanen et al. 2000; Sah et al. 2003; LeDoux 2007). Among these, the basolateral complex of the amygdala (BLA), which includes the lateral (LA) and basal (BA) nuclei and the central amygdala (CE), divided into the lateral (CEl)
Cell Tissue Res
and medial (C
Data Loading...
