Neutrophil Counts to High-Density Lipoprotein Cholesterol Ratio: a Potential Predictor of Prognosis in Acute Ischemic St
- PDF / 924,114 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 34 Downloads / 170 Views
ORIGINAL ARTICLE
Neutrophil Counts to High-Density Lipoprotein Cholesterol Ratio: a Potential Predictor of Prognosis in Acute Ischemic Stroke Patients After Intravenous Thrombolysis Guangyong Chen 1 & Naiping Yang 1,2 & Junli Ren 1,2 & Yibo He 1,2 & Honghao Huang 1,2 & Xueting Hu 1,2 & Jiamin Shen 1,2 & Chenguang Yang 1,2 & Tian Zeng 1,2 & Jingyu Hu 1,2 & Wangyong Tong 1,2 & Dehao Yang 3 & Yongyin Zhang 1 Received: 20 April 2020 / Revised: 15 August 2020 / Accepted: 18 August 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Neutrophil counts to high-density lipoprotein cholesterol ratio (NHR) is a relatively new and readily available indicator, and our study aimed to demonstrate its relationship with short-term prognosis after intravenous thrombolysis in acute ischemic stroke (AIS) patients and to make a simple comparison with other prognostic indicators. We compared demographic and laboratory characteristics of AIS patients and healthy controls and grouped AIS patients according to NHR tertiles to contrast 3-month outcomes. Univariate and multivariate regression analyses were carried to further analyze the relationship between NHR and prognosis. Moreover, we compared the accuracy of several factors using receiver-operating characteristic curve. NHR levels of AIS patients were higher than those of healthy controls (p < 0.001). The NHR levels were significantly higher in AIS patients with poor prognosis than those with good prognosis (p = 0.001) and were higher in patients with severe stroke than those with mild stroke (p = 0.011). Multivariate logistic regression analysis indicated that elevated NHR was an independent predictor of poor outcomes (odds ratio = 4.570; 95% CI, 1.841–11.340; p = 0.001). High NHR levels were associated with poor 3-month outcomes after intravenous thrombolysis in AIS patients. Keywords Neutrophil counts to high-density lipoprotein cholesterol ratio . Prognosis . Acute ischemic stroke . Intravenous thrombolysis
Introduction Acute ischemic stroke (AIS) is a kind of disease with high disability and mortality, which is caused by the stenosis or occlusion of the blood supply artery of the brain, the ischemia and hypoxia of the brain tissue, leading to the necrosis of the Guangyong Chen, Naiping Yang, and Junli Ren are co-first author * Dehao Yang [email protected] * Yongyin Zhang [email protected] 1
Department of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, No.108 Wansong Road, Wenzhou 325000, Zhejiang, China
2
School of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, China
3
Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
brain parenchyma, and then, the clinical symptoms of the loss of nerve function occur (Sommer 2017). In China, the social and family burden caused by stroke has increased at a visible rate in the last 30 years, especially by ischemic stroke (Wang et al. 2017). Intravenous injection of recombinant tissue plasmi
Data Loading...
