Neutrophil extracellular traps-associated markers are elevated in patients with systemic lupus erythematosus
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Rheumatology International https://doi.org/10.1007/s00296-019-04426-1
INTERNATIONAL
OBSERVATIONAL RESEARCH
Neutrophil extracellular traps‑associated markers are elevated in patients with systemic lupus erythematosus Ivica Jeremic1 · Olivera Djuric2 · Milos Nikolic3 · Marina Vlajnic4 · Aleksandra Nikolic4 · Dragica Radojkovic4 · Branka Bonaci‑Nikolic5 Received: 7 June 2019 / Accepted: 12 August 2019 © Springer-Verlag GmbH Germany, part of Springer Nature 2019
Abstract Neutrophil extracellular traps (NETs) are the main source of autoantigens in systemic lupus erythematosus (SLE). The aim of this study was to evaluate the clinical importance of NETs-associated markers in SLE. We compared NETs-associated markers in SLE patients (n = 111) with healthy controls (n = 50). Moreover, in 35 patients with drug-naïve SLE (n = 35), we investigated correlation between NETs-associated markers [DNase I concentration, myeloperoxidase (MPO) activity, anti-MPO antibodies, cell-free DNA (cfDNA), NETolytic activity] with serological parameters [anti-dsDNA antibodies, C3, C4 and B-cell activating factor (BAFF) levels] and disease activity measured by modified SLE Disease Activity Index (M-SLEDAI-2K). In comparison with healthy controls, SLE patients had higher cfDNA, MPO activity, anti-MPO antibodies (p
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