Nimesulide
- PDF / 141,500 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 45 Downloads / 137 Views
1
S
Stevens-Johnson syndrome, leading to fatal bronchiolitis obliterans in a child: case report A 5-year-old boy developed Stevens-Johnson syndrome (SJS), leading to fatal bronchiolitis obliterans while receiving nimesulide. The boy was prescribed oral nimesulide for a mild upper respiratory illness [dosage not stated]. Two days later, he developed red eyes and a generalised maculopapular rash, associated with a burning sensation. Over the following 2 days, the lesions became vesiculobullous, with a "target lesion" appearance. He was diagnosed with SJS and admitted. He developed a cough and respiratory distress 2 weeks later. The boy received antibacterials; however, his respiratory distress persisted. Three months after the reaction onset, he was referred to another hospital with an oxygen saturation of 94% on room air. Chest examination revealed bilateral biphasic wheezing and crackles. Imaging analysis led to a diagnosis of bronchiolitis obliterans. He received oxygen, β-adrenergic receptor agonists, budesonide, prednisolone and azathioprine. However, his respiratory distress persisted and he died 1 year later. Author comment: "SJS in our patient was probably owing to ingestion of nimesulide as there was a temporal association between the intake of the drug and appearance of the characteristic skin lesions." Dogra S, et al. Fatal bronchiolitis obliterans complicating Stevens-Johnson syndrome following treatment with nimesulide: A case report. Annals of Tropical Paediatrics 31: 259-261, No. 3, Aug 2011. Available from: URL: http:// 803060789 dx.doi.org/10.1179/1465328111y.0000000019 - India
0114-9954/10/1371-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Reactions 1 Oct 2011 No. 1371
Data Loading...
