Nitrogenation Strategy for the Synthesis of Carbamides
In this chapter, the synthesis of carbamides and their analogues such as carbamoyl azides through N atoms incorporation strategy with C–H and/or C–C bond cleavage is summarized. Azides considered as nitrogen sources with various oxidants are efficiently e
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Nitrogenation Strategy for the Synthesis of N-containing Compounds
Nitrogenation Strategy for the Synthesis of N-containing Compounds
Ning Jiao Editor
Nitrogenation Strategy for the Synthesis of N-containing Compounds
123
Editor Ning Jiao School of Pharmaceutical Sciences Peking University Beijing China
ISBN 978-981-10-2811-3 DOI 10.1007/978-981-10-2813-7
ISBN 978-981-10-2813-7
(eBook)
Library of Congress Control Number: 2016954629 © Springer Nature Singapore Pte Ltd. 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #22-06/08 Gateway East, Singapore 189721, Singapore
Preface
It is difficult to imagine chemistry without N-containing compounds, which occupy the significant position of living matter, pharmaceuticals, dyes, and materials. Therefore, the construction of C–N bond for the preparation of N-containing compounds has always been the important topic in organic synthesis. In the past century, substitution reactions (both nucleophilic and electrophilic amination), cross-coupling (including the named Ullmann reaction, Buchwald–Hartwig cross-coupling, and Chan–Evans–Lam coupling), nitrene insertion, cycloaddition, click chemistry, condensation and rearrangement reactions have been elegantly developed and widely applied for the C–N bond construction and therefore incorporate N-partners into substrates. Among them, the direct C–N bond formation through C–H/C–C bond functionalization is of great importance because it enables the direct conversion from simple hydrocarbons to N-containing compounds. Numerous elegant reviews in this area have been recently published on C–H amination and amidation. In recent years, the emerging methodologies on the direct incorporation of only N, NH, or NH2 atoms into substrates for the construction N-containing compounds attract considerable at
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