No evidence of occult HBV infection in population born after mass vaccination
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Wien Med Wochenschr https://doi.org/10.1007/s10354-020-00748-z
No evidence of occult HBV infection in population born after mass vaccination Mohammad Reza Aghasadeghi · Arezoo Aghakhani · Setareh Mamishi · Farahnaz Bidari-Zerehpoosh · Mohammad-Taghi Haghi Ashtiani · Shahram Sabeti · Mohammad Banifazl · Afsaneh Karami · Anahita Bavand · Amitis Ramezani
Received: 28 September 2019 / Accepted: 16 March 2020 © Springer-Verlag GmbH Austria, ein Teil von Springer Nature 2020
Summary Despite access to efficient hepatitis B virus (HBV) vaccine and universal immunization schedules, HBV infection remains a global health concern. HBV infection has decreased by this program. Nevertheless, breakthrough infections occur due to generation of occult HBV infection (OBI) and surface gene mutants in the immunized population. We aimed to determine the presence of OBI in a population born after initiation of nationwide HBV vaccination in Tehran, Iran. A HBV mass vaccination schedule was launched in Iran in 1993. For this study, we enrolled 1120 cases younger than 24 years. ELISA was applied to evaluate the presence of HBsAg, anti-HBs and anti-HBc. HBV-DNA presence was determined in all HBsAg-negative cases using nested polymerase chain reaction. The prevalence of HBsAg, anti-HBc and anti-HBs was 0.1, 0.54 and 39.9% respectively. Out of 6 anti-HBc-positive individuals, 4 cases also
had anti-HBs. One case revealed HBsAg co-existence and the other one showed isolated anti-HBc. HBVDNA was not detected in HBsAg-negative specimens. A very low prevalence of HBsAg and isolated anti-HBc was observed and no occult HBV infection was detected. It seems that evasion mutants are not a potential threat for HBV universal immunization efficacy in the vaccinated population.
M. R. Aghasadeghi Hepatitis and AIDS Dept., Pasteur Institute of Iran, Tehran, Iran [email protected]
F. Bidari-Zerehpoosh · S. Sabeti Pathology Ward, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
A. Aghakhani · A. Bavand · A. Ramezani () Clinical Research Dept., Pasteur Institute of Iran, Pasteur Ave., 13164 Tehran, Iran [email protected] A. Aghakhani [email protected] A. Bavand [email protected] S. Mamishi Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran [email protected]
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Keywords Expanded program of immunization · Chronic hepatitis B · Vaccination · Occult HBV · Infection
Introduction Chronic hepatitis B (CHB) is a major global health concern due to its remarkable morbidity and mortality. It is the main reason of almost 50% of global cases
F. Bidari-Zerehpoosh [email protected] S. Sabeti [email protected] M.-T. Haghi Ashtiani Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran [email protected] M. Banifazl Iranian Society for Support of Patients with Infectious Disease, Tehran, Iran [email protected] A. Karami Zanjan University of Medical Sciences, Zanjan, Iran dr.akarami@yaho
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