Nonspecific Removal of Sepsis Mediators
Sepsis is a growing clinical problem in our society, with an estimated annual incidence rate of above 300 cases per 100,000 people and mortality that exceeds 30% in those individuals suffering the disease (Esteban et al. 2007; Angus et al. 2001). Despite
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Sepsis New Strategies for Management
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Sepsis New Strategies for Management
Jordi Rello • Marcos I. Restrepo Editors
Sepsis New Strategies for Management
Jordi Rello, MD, PhD Critical Care Department – Joan XXIII University Hospital Universidad Rovira & Virgili and Institut Pere Virgili CIBER Enfermedades Respiratorias Doctor Mallafre Guasch, 4, 43007 Tarragona, Spain [email protected]
ISBN 978-3-540-79000-6
Marcos I. Restrepo, MD, MSc Division Pulmonary and Critical Care Medicine San Antonio, TX 78229-4404, USA Department of Medicine University of Texas Health Science Center at San Antonio San Antonio, TX, USA Veterans Evidence-Based Research Dissemination Implementation Center (VERDICT) South Texas Veterans Health Care System Audie L. Murphy Division 7400 Merton Minter Blvd (11C6) San Antonio, TX 78229-4404, USA [email protected]
e-ISBN 978-3-540-79001-3
DOI:10.1007/978-3-540-79001-3 Library of Congress Control Number: 2008925640 © 2008 Springer-Verlag Berlin Heidelberg This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permissions for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Cover design: eStudio Calamar Steinen, Barcelona Printed on acid-free paper 9 8 7 6 5 4 3 2 1 springer.com
Preface
Infectious-related mortality has remained an important problem around the world, and the majority of these deaths are related to pneumonia and sepsis. Although new interventions have emerged over the last decade, the mortality rates for these illnesses have remained significantly high and represent an important health care problem. This book is intended to address new concepts in medical care for a wide variety of clinicians who are involved in the care of patients with pneumonia and sepsis. This material is a compendium that goes from basic science research regarding genetics in sepsis and the impact of inflammation and aging in pneumococcal disease to new and future interventions translating basic information into clinical practice. Other topics covered in this book include issues regarding antibiotic therapy, such as other ro
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