Novel Agents in Neuropathic Pain, the Role of Capsaicin: Pharmacology, Efficacy, Side Effects, Different Preparations
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OTHER PAIN (N VADIVELU AND AD KAYE, SECTION EDITORS)
Novel Agents in Neuropathic Pain, the Role of Capsaicin: Pharmacology, Efficacy, Side Effects, Different Preparations O. Morgan Hall 1 & Alaina Broussard 2 & Tierra Range 2 & Michelle A. Carroll Turpin 3 & Savannah Ellis 4 & Victoria M. Lim 5 & Elyse M. Cornett 4 & Alan David Kaye 6
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose of Review Capsaicin is a natural substance used to treat neuropathic pain because of its ability to be used in a more direct form on patients and efficiently treat their pain without the amount of side effects seen in the use of oral medications. Recent Findings Currently, the treatments for neuropathic pain are, control of the underlying disease process, then focused on symptomatic relief with pharmacotherapy, topical analgesics, or other interventions. When all pharmacological agents fail to relieve the pain, interventional strategies can be considered, such as neural blocks, spinal cord stimulation, and intrathecal administered medications. The response to current treatment of neuropathic pain is only modest relief of symptoms. Multiple treatment options may be attempted, while ultimately leaving patients with refractory neuropathic pain. For these reasons, a better treatment approach to neuropathic pain is greatly needed. Summary Overall, capsaicin has great potential for becoming a first- or second-line treatment for neuropathic pain, and for becoming a therapeutic option for many other neuropathic pain-related disease states. Keywords Neuropathic pain . Capsaicin . Pain relief . Pharmacology
This article is part of the Topical Collection on Other Pain * Elyse M. Cornett [email protected] O. Morgan Hall [email protected] Alaina Broussard [email protected] Tierra Range [email protected] Michelle A. Carroll Turpin [email protected] Savannah Ellis [email protected] Victoria M. Lim [email protected]
Alan David Kaye [email protected]; [email protected] 1
Department of Anesthesiology, LSU School of Medicine, New Orleans, LA, Room 656, 1542 Tulane Ave, New Orleans, LA 70112, USA
2
Department of Anesthesiology, Ochsner Medical Center, 1514 Jefferson Hwy, New Orleans, LA 70121, USA
3
Department of Biomedical Sciences, College of Medicine, University of Houston, 4849 Calhoun Rd., Houston, TX 77204, USA
4
Department of Anesthesiology, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA
5
Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, 5777 E Mayo Blvd, Phoenix, AZ 85054, USA
6
Department of Anesthesiology and Pharmacology, Toxicology, and Neurosciences, Louisiana State University School of Medicine, Shreveport, LA, USA
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Introduction Neuropathic pain is typically described as damage or dysfunction of nervous tissue that is perceived by the brain as pain via the somatosensory system. The etiology of neuropathic pain is very broad including genetic, metabolic, direct injury, vascular, compression, immunologic, infect
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