Occult Hepatitis B Infection
Occult hepatitis B infection is a unique disease entity defined by detectable hepatitis B virus DNA in the sera and/or livers in subjects who are negative for HBsAg. OBI can be classified by serology. It can also be classified according to the medical his
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Jia-Horng Kao Ding-Shinn Chen Editors
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Hepatitis B Virus and Liver Disease
Jia-Horng Kao • Ding-Shinn Chen Editors
Hepatitis B Virus and Liver Disease
Editors Jia-Horng Kao Graduate Institute of Clinical Medicine National Taiwan University College of Medicine Taipei, Taiwan
Ding-Shinn Chen Graduate Institute of Clinical Medicine National Taiwan University College of Medicine Genomics Research Center Academia Sinica Taipei, Taiwan
ISBN 978-981-10-4842-5 ISBN 978-981-10-4843-2 (eBook) https://doi.org/10.1007/978-981-10-4843-2 Library of Congress Control Number: 2017960208 © Springer Nature Singapore Pte Ltd. 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
To our mentor Professor Juei-Low Sung Jia-Horng Kao Ding-Shinn Chen In memory of my parents Ping-Pei Chen and Shiu-Chin Tseng Chen By Ding-Shinn Chen To my parents Shi-Yang Kao and Wen-Shu Ho By Jia-Horng Kao
Foreword
This compact monograph represents a welcomed update on hepatitis B virus (HBV) and the disease it causes. The 17 chapters review the full spectrum of issues regarding HBV—its structure, molecular virology, replicative life cycle, immune pathogenesis, modes of transmission, epidemiology, natural history, complications, prevention, and treatment. Special chapters deal with the important issues of maternal-infant transmission; the disease in children, in immunosuppressed individuals, and in hepatitis C virus-, hepatitis D virus-, and human immunodeficiency virus-coinfected individuals; carcinogenesis; fibrosis progression; noninvasive means of assessment; and the needs for future basic and translational research. The authors are int
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