Optimum Cavity Length of a pTFET-Based Biosensor for Successful and Accurate Sensing of a Wide Range of Biomolecules
In this paper, for the first time, a rigorous analysis of determining minimum number of biomolecules and maximum length of the nanogap cavity, used to entrap biomolecules for the detection purpose, has been done. A pTFET-based biosensor (pTB-sensor) devic
- PDF / 591,915 Bytes
- 14 Pages / 439.37 x 666.142 pts Page_size
- 21 Downloads / 147 Views
Abstract In this paper, for the first time, a rigorous analysis of determining minimum number of biomolecules and maximum length of the nanogap cavity, used to entrap biomolecules for the detection purpose, has been done. A pTFET-based biosensor (pTB-sensor) device is being proposed, and the corresponding detection sensitivity in terms of threshold voltage (V th )—sensitivity, threshold voltage (V th )—shift, subthreshold swing (SS) sensitivity, subthreshold swing (SS) shift, ON current/OFF current (I ON /I OFF )—shift, leakage power (Pleak )—sensitivity is determined. It is found that the minimum number of biomolecules or minimum detection limit is 2 for Myoglobin and Apomyoglobin, while the same is 3 for Protein-G, FerricytochromeC, and Ferrocytochrome-C, respectively. The maximum biomolecules required for successful detection are found to be 5 for Myoglobin and Apomyoglobin, while the same is 7 for Protein-G, Ferricytochrome-C, and Ferrocytochrome-C, respectively, with 78%, 67%, 41%, 55%, and 50% V th —sensitivity and 83%, 74%, 53%, 63%, and 58% SS sensitivity for Apomyoglobin, Myoglobin, Protein-G, Ferrocytochrome-C, and Ferricytochrome-C, respectively. This leads to the minimum cavity length of 8 nm and maximum or optimum cavity length to be 20 nm, respectively, for the detection of all the five biomolecules successfully allowing space for scaling down of the channel length to sub-100 nm technology node. Keywords Detection limit · Maximum cavity length · Nanogap cavity · pTFET-based biosensor
S. Gayen (B) · S. Tewari · A. Chattopadhyay Department of Radio Physics and Electronics, University of Calcutta, Kolkata, India e-mail: [email protected] S. Tewari e-mail: [email protected] A. Chattopadhyay e-mail: [email protected] © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2021 V. Nath and J. K. Mandal (eds.), Proceedings of the Fourth International Conference on Microelectronics, Computing and Communication Systems, Lecture Notes in Electrical Engineering 673, https://doi.org/10.1007/978-981-15-5546-6_16
187
188
S. Gayen et al.
1 Introduction Over the last few decades, electronic biosensors or e-biosensors have gained a lot of popularity and became a topic of great interest in the interdisciplinary research field, due to their wide range of applications in different fields, starting from medical diagnosis to the detection of pollutants in environment, ultimately leading to the wellbeing of the human society [1–3]. Due to the label-free, hence economic detection process, easy scalability and compatibility with conventional CMOS process flow, the FET-based e-biosensors become attractive choice for the researchers nowadays [4– 6]. From the detection sensitivity point of view, FET-based devices show maximum sensitivity in subthreshold regime of the device operation. Then again, due to the continuous device miniaturization over the last few decades in search for performance benefit, in terms of speed of operation, power dissipation, packa
Data Loading...
