Outcomes of 42 pregnancies in 14 women with cartilage-hair hypoplasia: a retrospective cohort study
- PDF / 848,306 Bytes
- 6 Pages / 595.276 x 790.866 pts Page_size
- 59 Downloads / 195 Views
Open Access
RESEARCH
Outcomes of 42 pregnancies in 14 women with cartilage‑hair hypoplasia: a retrospective cohort study Elina Holopainen1,2* , Svetlana Vakkilainen2,3,4 and Outi Mäkitie2,3,4,5
Abstract Background: Cartilage-hair hypoplasia (CHH) is a rare skeletal dysplasia characterized by disproportionate short stature, immunodeficiency, anemia and risk of malignancies. All these features can affect pregnancy and predispose to maternal and fetal complications. This study aimed to evaluate obstetric history and maternal and fetal outcomes in women with CHH. Methods: Among 47 Finnish women with CHH, we identified 14 women with ICD codes related to pregnancies, childbirth and puerperium in the National Hospital Discharge Registry and obtained detailed data on gynecologic and obstetric history with a questionnaire. Offspring birth length and weight were collected and compared with population-based normal values. Results: There were altogether 42 pregnancies in 14 women (median height 124 cm, range 105–139 cm; 4′1′′, range 3′5′′–4′7′’). Twenty-six pregnancies (62%), including one twin pregnancy, led to a delivery. Miscarriages, induced abortions and ectopic pregnancies complicated 9, 5, and 2 pregnancies, respectively. Severe pregnancy-related complications were rare. All women with CHH delivered by cesarean section, mostly due to evident cephalo-pelvic disproportion, and in 25/26 cases at full-term. In the majority, the birth length (median 48 cm, range 45.5–50 cm; 1′7′′, range 1′6′′–1′8′′) and weight (3010 g, range 2100–3320 g; 6.6 lb, range 4.6–7.3 lb) of the offspring in full-term singleton pregnancies was normal. Conclusions: Despite CHH mothers’ significant short stature and other potential CHH-related effects on pregnancy outcome, most pregnancies lead to a term cesarean section delivery. Since fetal growth was generally unaffected, cephalo-pelvic disproportion was evident and planned cesarean section should be contemplated in term pregnancies. Keywords: Pregnancy, Cartilage-hair hypoplasia, Obstetric, Cesarean section, Miscarriage Background Bone dysplasia, small maternal height and disproportion can all affect fertility and natural course of pregnancy, and may predispose to pregnancy and obstetric
*Correspondence: [email protected] 1 Department of Reproductive Medicine, Obstetrics and Gynecology, Helsinki University Hospital and University of Helsinki, P.O. Box 140 00029, Helsinki, Finland Full list of author information is available at the end of the article
complications affecting perinatal outcomes. Women with short stature may suffer from respiratory distress during pregnancy and experience more cephalo-pelvic disproportion (CPD) leading to high rate of cesarean deliveries (CS) [1, 2]. Some studies have previously been performed on maternal and fetal outcome in different bone dysplasias. Pregnancies in patients with osteogenesis imperfecta can be complicated with antepartum hemorrhage, placenta abruption, intrauterine growth restriction (IUGR)
© The Author(s) 2020. Open Access This artic
Data Loading...
