Pediatric infection and sepsis in five age subgroups: single-center registry

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Wien Med Wochenschr https://doi.org/10.1007/s10354-020-00787-6

Pediatric infection and sepsis in five age subgroups: singlecenter registry Michael M. Hermon · Theresa Etmayr · Jennifer Bettina Brandt · Kambis Sadeghi · Gudrun Burda · Johann Golej

Received: 9 June 2020 / Accepted: 28 September 2020 © The Author(s) 2020

Summary Background Sepsis is, worldwide, one of the leading causes of death among infants and children. Over the past two decades, mortality rates have declined due to advanced treatment options; however, the incidence of sepsis and septic shock is still on the rise in many hospital settings. The objective of this study was to evaluate the course of this disease in pediatric intensive care patients. Methods An evaluation of pediatric patients in the intensive care unit diagnosed with infections or sepsis between 2005 and 2015 was performed via a retrospective exploratory data analysis. Results During the observational period, 201 patients were diagnosed with infection or sepsis. The study population was divided into five age subgroups. The majority of patients were newborns, infants, and toddlers. Forty percent had sepsis; 6% had septic shock. Viral infection was the most prevalent (59%). The overall survival rate was 83%; newborns and adolescents had the lowest survival rates. Conclusion With this registry, children divided into five age subgroups with infection or sepsis were evaluated and treatment strategies were examined. We have shown that our findings on children treated in our pediatric intensive care unit conform with current literature about pediatric sepsis. In addition to maintaining strict hygiene standards, optimal aspects M. M. Hermon, MD () · J. B. Brandt, MD · K. Sadeghi, MD · G. Burda, MD · J. Golej, MD Department of Pediatrics, Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Medical University of Vienna, Währinger Gürtel 18–20, 1090 Vienna, Austria [email protected] T. Etmayr, MD Department of Pediatrics, Ordensklinikum Linz, Barmherzige Schwestern Elisabethinen, Linz, Austria

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of sepsis care should be stringently observed, such as the quick administration of empirical broad-spectrum antibiotics, initial adequate fluid resuscitation, and a reliable and frequent routine of source control. Keywords Pediatric sepsis · Severe infection · Pediatric intensive care · Extracorporeal membrane oxygenation · Multi organ failure

Pädiatrische Infektion und Sepsis in 5 Altersuntergruppen: Einzelzentrumsregister Zusammenfassung Hintergrund Sepsis ist weltweit eine der häufigsten Todesursachen bei Säuglingen und Kindern. In den letzten 2 Jahrzehnten sank die Sterblichkeitsrate durch verbesserte Behandlungsoptionen, die Inzidenz der Sepsis und des septischen Schocks nimmt jedoch weiterhin zu. Ziel dieser Studie war es, den Krankheitsverlauf bei pädiatrischen IntensivpatientInnen mit Sepsis oder Infektion zu beurteilen. Methodik Es erfolgte eine retrospektive explorative Datenanalyse von pädiatrischen PatientInnen, die zwischen 2005 und 2015 aufgrund einer