Performance characteristics of a novel clustered multi-pinhole technology for simultaneous high-resolution SPECT/PET
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ORIGINAL ARTICLE
Performance characteristics of a novel clustered multi-pinhole technology for simultaneous high-resolution SPECT/PET Kenta Miwa1,2,3 • Masayuki Inubushi4 • Yasuto Takeuchi1 • Tetsuro Katafuchi5 Mitsuru Koizumi1,2 • Tsuneo Saga1 • Masayuki Sasaki3
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Received: 18 January 2015 / Accepted: 19 March 2015 Ó The Japanese Society of Nuclear Medicine 2015
Abstract Objective Versatile emission computed tomography (VECTor) for small-animal imaging enables fully simultaneous SPECT/PET image acquisition based on clustered multi-pinhole collimation. The present study experimentally evaluated the detailed performance characteristics of the clustered multi-pinhole system for simultaneous 99mTc and 18F imaging from the user perspective. Methods Spatial resolution, sensitivity, count rate linearity were determined for the VECTor system (MILabs). Two hot-rod micro-resolution phantoms with 6 sectors were created to test the resolution of 99mTc and 18F. Sensitivity and count rate linearity were measured by scanning K. Miwa and M. Inubushi contributed equally. & Masayuki Inubushi [email protected] Kenta Miwa [email protected] 1
Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, Japan
2
Department of Nuclear Medicine, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan
3
Division of Medical Quantum Science, Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
4
Division of Nuclear Medicine, Department of Radiology, Kawasaki Medical School, 577 Matsushima Kurashiki, Okayama 701-0192, Japan
5
Department of Radiological Technology, Gifu University of Medical Science, 795-1 Nagamine, Ichihiraga, Seki-shi, Gifu 501-3892, Japan
99m
Tc and 18F point sources positioned at the center of the field of view. Furthermore, we quantified the influence of 18 F on 99mTc SPECT images. The ratios of SPECT counts on the 99mTc-only and simultaneous 18F-99mTc at various time points were evaluated as a function of the 18Fto-99mTc activity concentration ratio. Results The 0.5-mm hot-rods can be visually distinguished in the 99mTc image, and 0.8-mm rods for 18F remained clearly visible. The point-source sensitivity was 2800 cps/MBq for 99mTc and 2899 cps/MBq for 18F, respectively. Count rates up to 120,000 cps for one bed position were linear for the activity. Spill-over from 18F into 99m Tc SPECT images was negligible when the activity concentration of the administered 18F solution exceeded that of the 99mTc solution by up to a factor of 2. Conclusions We evaluated the performance characteristics of the VECTor that lead to determination of the optimal administered doses of 99mTc and 18F tracers. We found that the VECTor achieved high resolution and high sensitivity as well as good 99mTc and 18F linearity. Simultaneous SPECT/PET imaging with 99mTc and 18F tracers, and stand-alone 99mTc and 18F imagi
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