Physiological and Pathological Functions of CARD9 Signaling in the Innate Immune System
Caspase recruitment domain protein 9 (CARD9) forms essential signaling complexes in the innate immune system that integrate cues from C-type lectin receptors and specific intracellular pattern recognition receptors. These CARD9-mediated signals are pivota
- PDF / 959,846 Bytes
- 27 Pages / 439.37 x 666.142 pts Page_size
- 68 Downloads / 186 Views
Contents 1 2 3 4 5 6
Introduction.......................................................................................................................... CARD9 Structure, Expression and Binding Partners ......................................................... CARD9 Activation and Innate CBM Complex Assembly ................................................ Effector Functions of CARD9 Signaling ............................................................................ Negative Regulation of CARD9 Signaling......................................................................... Physiological Functions of CARD9 Signaling in Host Protection .................................... 6.1 CARD9 Signaling in Antifungal Immunity............................................................... 6.2 CARD9 in Antibacterial Defense............................................................................... 6.3 CARD9 in Immunity to Parasites .............................................................................. 6.4 CARD9 Signaling upon Viral Recognition ............................................................... 7 CARD9 Signaling in Noninfectious Inflammation and Cancer Models............................ 8 Genetic Alterations of CARD9 in Human Disease............................................................. 9 Conclusions and Therapeutic Perspective........................................................................... References ..................................................................................................................................
L. Vornholz J. Ruland (&) TUM School of Medicine, Institute of Clinical Chemistry and Pathobiochemistry, Technical University of Munich, 81675 Munich, Germany e-mail: [email protected] TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, 81675 Munich, Germany J. Ruland German Cancer Consortium (DKTK), Heidelberg, Germany German Center for Infection Research (DZIF), Munich Partner Site, Munich, Germany Current Topics in Microbiology and Immunology https://doi.org/10.1007/82_2020_211 © Springer Nature Switzerland AG 2020
2
L. Vornholz and J. Ruland
Abstract Caspase recruitment domain protein 9 (CARD9) forms essential signaling complexes in the innate immune system that integrate cues from C-type lectin receptors and specific intracellular pattern recognition receptors. These CARD9-mediated signals are pivotal for host defense against fungi, and they mediate immunity against certain bacteria, viruses and parasites. Furthermore, CARD9-regulated pathways are involved in sterile inflammatory responses critical for immune homeostasis and can control pro- and antitumor immunity in cancer microenvironments. Consequently, multiple genetic alterations of human CARD9 are connected to primary immunodeficiencies or prevalent inflammatory disorders in patients. This review will summarize our current understanding of CARD9 signaling in the innate immune system, its physiological and pathological functions and their implications for huma
Data Loading...
