Population pharmacokinetics and renal toxicity of cisplatin in cancer patients with renal dysfunction

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ORIGINAL ARTICLE

Population pharmacokinetics and renal toxicity of cisplatin in cancer patients with renal dysfunction Tomoko Morita‑Ogawa1   · Hiroki Sugita1 · Hironobu Minami2 · Takuhiro Yamaguchi3 · Kazuhiko Hanada1 Received: 2 May 2020 / Accepted: 8 September 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020

Abstract Purpose  The pharmacokinetics (PKs) of cisplatin have not been investigated in patients with renal dysfunction, characterized by creatinine clearance (Ccr) 

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