Population Pharmacokinetics of Clotting Factor Concentrates and Desmopressin in Hemophilia

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Population Pharmacokinetics of Clotting Factor Concentrates and Desmopressin in Hemophilia Tim Preijers1   · Lisette M. Schütte2   · Marieke J. H. A. Kruip2 · Marjon H. Cnossen3 · Frank W. G. Leebeek2 · Reinier M. van Hest1 · Ron A. A. Mathôt1,4

© The Author(s) 2020

Abstract Hemophilia A and B are bleeding disorders caused by a deficiency of clotting factor VIII and IX, respectively. Patients with severe hemophilia (