Precision Molecular Pathology of Liver Cancer
This volume provides the most updated knowledge on the advancement of molecular pathogenesis, molecular diagnosis, and therapy development for hepatocellular carcinoma (HCC). Topics covered include the etiology and pathogenesis of HCC, recent advances in
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Chen Liu Editor
Precision Molecular Pathology of Liver Cancer
Molecular Pathology Library Series Editor: Philip T. Cagle Houston, TX USA
More information about this series at http://www.springer.com/series/7723
Chen Liu Editor
Precision Molecular Pathology of Liver Cancer
Editor Chen Liu Department of Pathology and Laboratory Medicine Rutgers Robert Wood Johnson Medical School and New Jersey Medical School Newark, New Jersey USA
ISSN 1935-987X ISSN 1935-9888 (electronic) Molecular Pathology Library ISBN 978-3-319-68080-4 ISBN 978-3-319-68082-8 (eBook) https://doi.org/10.1007/978-3-319-68082-8 Library of Congress Control Number: 2017962859 © Springer International Publishing AG 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
Hepatocellular carcinoma (HCC) is the predominant primary malignant cancer in the liver. It is one of the most common and malignant cancers in the world. There are 700,000 deaths due to HCC every year. The cancer incidence is increasing in many countries, including the United States. Unfortunately, the treatment options are very limited compared to other human cancers. Many clinical trials have been conducted over the years, but the results are generally disappointing. The high failure rate for clinical trials is partially attributed to lack of adequate biomarkers for patient selection. Developing molecular markers is paramount for early diagnosis and optimal treatment of HCC. This book provides the most updated knowledge on the advancement of molecular pathogenesis, molecular diagnosis, and therapy development. The authors are experts in the topics they have contributed. Besides reviewing t
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