Preserved peritoneal function by short-term two-day peritoneal rest in hemodialysis combination therapy patients
- PDF / 642,017 Bytes
- 5 Pages / 595.276 x 790.866 pts Page_size
- 8 Downloads / 170 Views
BRIEF COMMUNICATION Artificial Kidney / Dialysis
Preserved peritoneal function by short‑term two‑day peritoneal rest in hemodialysis combination therapy patients Atsushi Ueda1,2 · Kei Nagai2 · Kunihiro Yamagata2 Received: 28 March 2020 / Accepted: 22 September 2020 © The Japanese Society for Artificial Organs 2020
Abstract Several reports have demonstrated that peritoneal rest (PR) is considered to preserve the peritoneal function in peritoneal dialysis (PD) patients. However, there has been no report that examines the peritoneal permeability before and after a shortterm PR of two days. We examined the effect of the two-day PR on peritoneal permeability. We observed and compared the daily PD ultrafiltration changes in the four PD and hemodialysis (HD) combination patients from the start of dialysis therapy throughout the total observation period of each case. Next, 6 months after the initiation of dialysis therapy we performed a set of peritoneal equilibrium tests (PET) before and after the 2-day PR. D/P creatinine, daily urine volume, daily ultrafiltration volume in PD, weekly residual renal creatinine clearance, and weekly PD creatinine clearance were measured. The daily PD ultrafiltration volume increased significantly after the 2-day PR, and gradually decreased over the last four days throughout the observation period in each patient. In the PET results, D/P creatinine in all patients decreased after the short-term PR, and accordingly the peritoneal ultrafiltration volume increased. However, urine volume, residual renal creatinine clearance, and peritoneal creatinine clearance did not change. The peritoneal permeability clearly decreased after the short-term PR. The repeated improvement in the PD ultrafiltration volume after the short-term PR implies that the peritoneal permeability alteration might be due to a reversible functional change in the initial dialysis period. These results suggest that a short-term PR may preserve the peritoneal function. Keywords Peritoneal dialysis · Peritoneal resting · Peritoneal permeability · Peritoneal ultrafiltration
Introduction In peritoneal dialysis (PD) patients, ultrafiltration failure (UFF) results in fluid overload and is one of the reasons for abandoning PD therapy. In previous reports, a longterm peritoneal rest (PR) decreased peritoneal permeability and increased ultrafiltration volume [1–3]. Also, in another report from Japan, PD patients were treated with combined hemodialysis (HD) and PR that was implemented 1 to 2 days a week. After three months with PR, peritoneal permeability decreased, and ultrafiltration volume improved [4]. * Atsushi Ueda au‑[email protected] 1
Department of Nephrology, Hitachi General Hospital, 2‑1‑1 Johnan‑chou, Hitachi, Ibaraki 317‑0077, Japan
Department of Nephrology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan
2
However, there has been no report that examines the peritoneal permeability before and after a short-term PR of two days. We examined the effect of a 2-day PR on peritoneal permeability.
Mater
Data Loading...
