Prevalence and risk factors of long-term proton pump inhibitors-associated hypomagnesemia: a cross-sectional study in ho
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Prevalence and risk factors of long‑term proton pump inhibitors‑associated hypomagnesemia: a cross‑sectional study in hospitalized patients Delfina Ana Recart1 · Augusto Ferraris1,2 · Carla Ines Petriglieri3 · Marina Alonso Serena1 · Maria Belen Bonella1 · Maria Lourdes Posadas‑Martinez1 Received: 18 August 2020 / Accepted: 5 September 2020 © Società Italiana di Medicina Interna (SIMI) 2020
Abstract Background Proton pump inhibitors (PPI)-related hypomagnesemia is a potentially life-threatening adverse event first described in 2006. PPIs are widely used in the general population. Information regarding prevalence and risk factors is scarce. We conducted a cross-sectional study in inpatients to evaluate prevalence and associated factors with hypomagnesemia in chronic PPIs users. This is a cross-sectional study of hospitalized adult patients with chronic use of PPIs from January 01, 2012, to December 31, 2018. Chronic use was defined as taking PPIs at least 6 months before hospital admittance. Data were collected from informatized medical records from a University Hospital (Hospital Italiano de Buenos Aires). Hypomagnesemia was defined as a value equal to or less than 1.7 mg/dl. The first hospitalization measurement was retrieved. Thirty-six percent of patients (95% CI 30–43) with chronic PPI use presented hypomagnesemia at admission. Patients with hypomagnesemia presented a higher prevalence of chronic kidney disease (18.6% vs 8%, p
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