Prevalence of low bone mineral density in inflammatory bowel disease and factors associated with it
- PDF / 643,225 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 33 Downloads / 239 Views
ORIGINAL ARTICLE
Prevalence of low bone mineral density in inflammatory bowel disease and factors associated with it Zohaib A. W. Khan 1 & Shiran Shetty 1 & Ganesh C. Pai 1
&
Kiran K. V. Acharya 2 & Ravishankar Nagaraja 3
Received: 29 July 2019 / Accepted: 29 April 2020 # Indian Society of Gastroenterology 2020
Abstract Background Patients with inflammatory bowel disease (IBD) have numerous risk factors for low bone mineral density (BMD). We aimed to study the prevalence of low BMD in IBD and the factors associated with it. Methods BMD was measured by radial quantitative ultrasound, and clinical and biochemical characteristics were compared in prospectively enrolled patients and healthy age and gender-matched controls. Chi-square test, t test for independent samples, analysis of variance (ANOVA), Mann–Whitney U test and Kruskal–Wallis H tests were used as appropriate for univariate analysis to compare the characteristics between patients with and without abnormal BMD. Binary logistic regression analysis was done to determine the factors associated with low BMD in IBD patients. Results One hundred and six patients (Crohn’s disease [CD] = 35, ulcerative colitis [UC] = 71) and 55 controls were included. Low BMD was equally prevalent in CD, UC and controls (42.9%, 36.6%, 36.4% respectively, p = 0.791). Serum calcium and vitamin D were significantly lower in IBD patients compared to controls (p < 0.001 and p = 0.003, respectively) but not between patients with low and normal BMD. Older age (Odds ratio [OR] = 66.12 [9.299–470.243], p < 0.001), late onset of disease (OR = 4.795 [1.067–21.543], p = 0.041) and absence of steroid usage (OR = 0.272 [0.089–0.832], p = 0.022) were significantly associated with low BMD. Conclusions The prevalence of low BMD in patients with IBD was similar to controls and this was associated with increasing age, late onset of disease, and absence of steroid usage. Judicious use of steroids can help preserve bone health in IBD.
Keywords Bone densitometry . Bone health . Bone mineral density . Corticosteroid . Crohn’s disease . Dual-energy X-ray absorptiometry . Inflammatory bowel disease . Quantitative ultrasound . Radial quantitative ultrasound . Ulcerative colitis . Vitamin D
Introduction Inflammatory bowel disease (IBD), a chronic inflammatory state which primarily affects the intestines, has several extraintestinal * Ganesh C. Pai [email protected] 1
Department of Gastroenterology and Hepatology, Kasturba Hospital, Manipal Academy of Higher Education, Manipal, Udupi 576 104, India
2
Department of Orthopedics, Kasturba Hospital, Manipal Academy of Higher Education, Manipal, Udupi 576 104, India
3
Department of Statistics, Manipal Academy of Higher Education, Manipal, Udupi 576 104, India
manifestations. Abnormal bone mineralization is one of the many skeletal system manifestations that have received attention [1]. Patients with IBD have multiple risk factors for low bone mineral density (BMD) such as corticosteroid usage [2], inflammatory state [3], malabsorption of calcium [
Data Loading...
