Prognostic value of pre-operative glucose-corrected maximum standardized uptake value in patients with non-small cell lu
- PDF / 445,535 Bytes
- 7 Pages / 595.276 x 790.866 pts Page_size
- 102 Downloads / 163 Views
ORIGINAL ARTICLE
Prognostic value of pre-operative glucose-corrected maximum standardized uptake value in patients with non-small cell lung cancer after complete surgical resection and 5-year follow-up Renske Konings1 • Matthijs H. van Gool2 • Martin P. L. Bard3 • Anthonie Zwijnenburg4 • Bart M. Titulaer4 • Tjeerd S. Aukema5 • Renato A. Valde´s Olmos5 • Karolina Sikorska6 • Houke M. Klomp2 • Herman Rijna1
Received: 26 August 2015 / Accepted: 22 February 2016 Ó The Japanese Society of Nuclear Medicine 2016
Abstract Introduction In this study we evaluated the value of preoperative glucose corrected maximum standard uptake value (GC-SUVmax) as prognostic factor in patients with early stage non-small cell lung cancer (NSCLC) after complete surgical resection. Methods This study was designed as a retrospectively evaluated single center study with prospective data registry. Inclusion criteria were: histologically proven stage I NSCLC, 18F-FDG-PET/CT scan prior to surgery, complete resection (R0) and follow up in our outpatient department. Exclusion criteria were: history of malignancy Preliminary results of this study were published in Lung Cancer vol. 71, suppl. 2, page S39, in Feb. 2011, and the topic was presented in a national meeting. R. Konings and M. H. van Gool contributed equally to this work. & Matthijs H. van Gool [email protected] 1
Department of Surgery, Spaarne Gasthuis, Haarlem, The Netherlands
2
Department of Surgical Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
3
Department of Pulmonology, Spaarne Gasthuis, Haarlem, The Netherlands
4
Department of Nuclear Medicine, Spaarne Gasthuis, Haarlem, The Netherlands
5
Department of Nuclear Medicine, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
6
Department of Biometrics, The Netherlands Cancer InstituteAntoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
other than NSCLC, diabetes and (neo) adjuvant therapy. Follow up period was 5 years. Results Between 2006 and 2008 a total of 33 patients (16 males, 17 females) met the inclusion criteria. SUVmax and GC-SUVmax were strongly correlated (Spearman’s q = 0.97). Five-year overall survival (OS) rate was 70 % (95 % CI = 56–87 %). Patients who died within 5 years of follow up had significantly higher pre-operative GCSUVmax (median = 10.6, IQR = 8.3–14.4) than patients who were alive at 5-year follow up (median = 6.4, IQR = 3.0–9.8), p = 0.04. SUVmax showed similar differences: 10.4 (8–12.9) vs. 6.6 (3.0–8.8), p = 0.047. The area under the receiver-operating characteristic (ROC) curve at 5 years was 0.70 (95 % CI = 0.50–0.90) for GCSUVmax and 0.71 (95 % CI = 0.51–0.91) for SUVmax (p = 0.75). Conclusion Pre-operative FDG tumor uptake in patients with NSCLC is predictive for survival after complete surgical resection. GC-SUVmax, as an additional value to SUVmax, may better approach competitive inhibition of FDG and glucose in tumors, however, in this study this potential adva
Data Loading...
