Prognostic value of tumoral and peritumoral magnetic resonance parameters in osteosarcoma patients for monitoring chemot
- PDF / 1,778,173 Bytes
- 12 Pages / 595.276 x 790.866 pts Page_size
- 61 Downloads / 174 Views
MUSCULOSKELETAL
Prognostic value of tumoral and peritumoral magnetic resonance parameters in osteosarcoma patients for monitoring chemotherapy response Yuewen Hao 1,2 & Rui An 2 & Yingsen Xue 3 & Fan Li 4 & Hong Wang 2 & Jianmin Zheng 2 & Linni Fan 5 & Jixin Liu 6 & Hongbin Fan 7 & Hong Yin 2 Received: 11 February 2020 / Revised: 25 August 2020 / Accepted: 22 September 2020 # The Author(s) 2020
Abstract Objectives To evaluate parameters of diffusion-weighted imaging (DWI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) as early imaging indicators of tumor histologic response to pre-operative neoadjuvant chemotherapy and as probable prognostic factors for event-free survival (EFS) and overall survival in osteosarcoma (OS) in both tumoral and peritumoral areas. Methods Thirty-four OS patients who received three courses of neoadjuvant chemotherapy followed by surgery during 2014–2018 were enrolled in this study. All patients underwent baseline and post-chemotherapy DWI and DCE-MRI. Lesion region was defined as the tumoral area and peritumoral area. Parameters of apparent diffusion coefficient, capacity transfer constant (Ktrans), elimination rate constant, extravascular extracellular space volume ratio (Ve), and initial area under the curve as well as corresponding differences between pre- and post-chemotherapy in lesion regions were evaluated. Receiver operating characteristic analysis was used to evaluate the diagnostic performance of these parameters. The associations of all parameters with tumor histologic response, EFS, and overall survival were also calculated. Results In the tumor area, moderate evidence was found that post-Ktrans was lower in responders as compared with that in poor responders (p = 0.04, false discovery rate [FDR] corrected), and ΔKtrans exhibited significant between-groups differences (p = 0.04, Bonferroni corrected; or p = 0.006, FDR corrected). Weak evidence for the between-groups difference was found in the Ve in the peritumoral area (p = 0.025 before treatment and p = 0.021 after treatment, uncorrected). Furthermore, lower post-Ktrans in the tumoral area and lower pre-Ve in the peritumoral area were significant prognostic indicators for longer EFS (p = 0.002, p = 0.026) and overall survival (p = 0.003, p = 0.023). Conclusions In OS, DWI and DCE-MRI parameters in both tumoral and peritumoral areas can reflect the chemotherapy response and prognosticate EFS and overall survival.
Yuewen Hao and Rui An contributed equally to this work. * Hongbin Fan [email protected]
4
Department of Health Statistics, Fourth Military Medical University, Xi’an, Shaanxi, China
* Hong Yin [email protected]
5
Department of Pathology, Fourth Military Medical University, Xi’an, Shaanxi, China
6
School of Life Science and Technology, Xidian University, Xi’an, Shaanxi, China
7
Department of Orthopaedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China
1
Department of Radiology, Xi’an Children’s Hospital, Xi’an, Shaanxi, China
2
Department of Radio
Data Loading...
