Prognostic value of volume-based metabolic parameters of 18 F-FDG PET/CT in ovarian cancer: a systematic review and meta
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ORIGINAL ARTICLE
Prognostic value of volume-based metabolic parameters of 18F-FDG PET/CT in ovarian cancer: a systematic review and meta-analysis Sangwon Han1,2 · Hyesung Kim3 · Yeon Joo Kim4 · Chong Hyun Suh1,5 · Sungmin Woo1,6 Received: 14 June 2018 / Accepted: 8 August 2018 © The Japanese Society of Nuclear Medicine 2018
Abstract Objective To perform a systematic review and meta-analysis on the prognostic value of 18F-FDG PET-derived volume-based parameters regarding metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in patients with ovarian cancer. Methods Pubmed and EMBASE databases were searched up to February 12, 2018 for studies which evaluated MTV or TLG as a prognostic factor in ovarian cancer with progression-free (PFS) and overall survival (OS) as the endpoints. Hazard ratios (HRs) were meta-analytically pooled using the random-effects model. Multiple subgroup analyses based on clinicopathological and PET variables were performed. Results Eight studies with 473 patients were included. The pooled HRs of MTV and TLG for PFS were 2.50 (95% CI 1.79–3.48; p 6
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