Progress in Molecular and Subcellular Biology
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Progress in Molecular and Subcellular Biology With Contributions by J. R. Bamburg, T. L. German, F. E. Hahn G. Knudson, R. F. Marsh, J. J. O'Neill
Edited by F. E. Hahn, D. J. Kopecko W. E. G. Muller Managing Editor: F. E. Hahn
Springer-Verlag Berlin Heidelberg New York Tokyo 1983
Professor Fred E. Hahn, Ph. D. Division of Communicable Diseases and Immunology Walter Reed Army Institute of Research Washington, D. C. 20307, USA
With 36 Figures
ISBN-13: 978-3-642-69230-7 e-ISBN-13: 978-3-642-69228-4 001: 10.1007/978-3-642-69228-4
Library of Congress Catalog Card Number 75-79748 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation. reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the German Copyright Law where copies are made for other than private use, a fee is payable to 'Verwertungsgesellschaft Wort', MOnchen
© by Springer-Verlag Berlin Heidelberg 1983 Softcover reprint of the hardcover 1st edition 1983 The use of registered names, trademarks etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Offsetprinting and Bookbinding: Konrad Triltsch, Graphischer Betrieb, 8700 WOrzburg. 2131/3130-543210
Contents
F.E. HAHN: Penicillin Until 1957 (With 11 Figures) A. B. C. D. E. F. G. H.
Introduction .....•......•.•..•.••.•...••...•...•.••.... The Discovery of Penicillin ..••••......•...•...•...•... Penicillin as a Chemotherapeutic Drug ...••.••..•..•.•.. Early Studies on Mode of Action •••....••..••••..••••... Paradoxical Inhibitory Zone Phenomena ....•.•..••...•..• Morphological Changes in Bacteria ...•..•...•.•••.••••.• Bacterial Lysis by Penicillin •••••••••••...•.••.•.•••.• Interference of Penicillin with Nucleic Acid and Protein Synthesis? •.•..•.••...•...••••••••....•.•..•..••...•••• I. Park's Nucleotides ....••.....•..•.•....••.............. J. Penicillin Binding by Bacteria .••..••.••..••..•.•..••.• References .•.•.•••••..••••••.••••.•••.....••.••.•..••..
1 2 4 5 6 8 10 12 14 16 19
G.B. KNUDSON: The Role of Inducible DNA Repair in W-Reactivation and Related Phenomena A. B. C. D. E. F.
Introduction ...........•••...•.........••••.•.......... Enzymatic Repair Systems in Bacteria and Their Viruses W-Reactivation and W-Mutagenesis ..••..••.••••..•••.••.. Direct and Indirect Prophage Induction •.•...••••..•.... Plasmid Mediated UV-Protection and Mutagenesis ......... Inducible "SOS"-Repair Functions ...•.•....•....••••.•.. References ••.........•••..••.•••.....•..••.••.•...•••..
22 22 24 30 31 31 33
J.R. BAMBURG: Biological and Biochemical Actions of Trichothecene Mycotoxins (With 9 Figures) A. B. C. D. E. F. G. H. I. J.
Introduction .......•...•••...........••.....•......•... Trichothecene Structure and Genesis ..•••..•.•.•.•.•••.. Detection of Trichothecenes •..••..
