Prokaryotic Chaperonins Multiple Copies and Multitude Functions
This book focuses on a topical and timely aspect of prokaryotic biology - the biology of prokaryotic multiple chaperonins. Chaperonins are a class of molecular chaperones, the proteins that assist folding of other proteins in the cell. The book begins wi
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C. M. Santosh Kumar Shekhar C. Mande Editors
Prokaryotic Chaperonins Multiple Copies and Multitude Functions
Heat Shock Proteins Volume 11
Series editors Alexzander A. A. Asea, Ph.D. Professor and VD for Research Innovations Deanship for Scientific Research, University of Dammam Dammam, Saudi Arabia Stuart K. Calderwood, Ph.D. Professor and Director Division of Molecular and Cellular Radiation Oncology Department of Radiation Oncology, Harvard Medical School of Beth Israel Deaconess Medical Center Boston, MA, USA
Heat Shock Proteins: key mediators of Health and Disease. Heat shock proteins (HSP) are essential molecules conserved through cellular evolution required for cells to survive the stresses encountered in the environment and in the tissues of the developing and aging organism. These proteins play the essential roles in stress of preventing the initiation of programmed cell death and repairing damage to the proteome permitting resumption of normal metabolism. Loss of the HSP is lethal either in the short-term in cases of acute stress or in the long-term when exposure to stress is chronic. Cells appear to walk a fine line in terms of HSP expression. If expression falls below a certain level, cells become sensitive to oxidative damage that influences aging and protein aggregation disease. If HSP levels rise above the normal range, inflammatory and oncogenic changes occur. It is becoming clear that HSP are emerging as remarkably versatile mediators of health and disease. The aim of this series of volumes is to examine how HSP regulation and expression become altered in pathological states and how this may be remedied by pharmacological and other interventions. More information about this series at http://www.springer.com/series/7515
C. M. Santosh Kumar • Shekhar C. Mande Editors
Prokaryotic Chaperonins Multiple Copies and Multitude Functions
Editors C. M. Santosh Kumar Institute of Microbiology and Infection – School of Biosciences University of Birmingham Birmingham West Midlands UK
Shekhar C. Mande Laboratory of Structural Biology National Centre for Cell Science Pune Maharashtra India
ISSN 1877-1246 ISSN 1877-1254 (electronic) Heat Shock Proteins ISBN 978-981-10-4650-6 ISBN 978-981-10-4651-3 (eBook) DOI 10.1007/978-981-10-4651-3 Library of Congress Control Number: 2017945831 © Springer Nature Singapore Pte Ltd. 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protecti
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