Psoriasis and Cardiovascular Risk: A Comprehensive Review
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REVIEW
Psoriasis and Cardiovascular Risk: A Comprehensive Review Walter Masson . Martı´n Lobo . Graciela Molinero
Received: March 20, 2020 Ó The Author(s) 2020
ABSTRACT Psoriasis is a systemic inflammatory disorder that involves complex pathogenic interactions between the innate and adaptive immune systems. Individuals with psoriasis have an increased risk of developing other chronic health diseases such cardiovascular disorders. The high incidence of cardiovascular events in the population with psoriasis could be explained by several mechanisms. The high prevalence of traditional cardiovascular risk factors and metabolic abnormalities contributes to the high cardiovascular burden in patients with psoriasis. Likewise, the presence of systemic inflammation in combination with metabolic abnormalities may act in a synergistic manner to increase cardiovascular risk in these patients. This review focused on epidemiologic and clinical evidence linking psoriasis to cardiovascular risk factors and cardiovascular
disease. We described the possible pathophysiological mechanisms that justify this association and analyzed the best way to stratify the cardiovascular risk in patients with psoriasis. We also described the usefulness of the therapies frequently used in cardiovascular prevention and analyzed the impact of the specific psoriasis medication on cardiovascular risk factors or major atherosclerotic events. Knowledge of the application of different cardiovascular prevention strategies could mean an advantage in performing the difficult task of estimating cardiovascular risk and treating cardiovascular risk factors in this particular group of patients.
Keywords: Cardiovascular disease; Cardiovascular risk factors; Cardiovascular risk stratification; Psoriasis; Statins Key Summary Points
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Psoriasis is a chronic inflammatory skin disease associated with increased cardiovascular morbidity and mortality.
W. Masson (&) Hospital Italiano de Buenos Aires, Pero´n 4190, C1199ABB Buenos Aires, Argentina e-mail: [email protected]
Patients with psoriasis have an increased prevalence of classic cardiovascular risk factors, but psoriasis may provide an additional and independent cardiovascular risk factor: inflammation.
W. Masson M. Lobo G. Molinero Council of Epidemiology and Cardiovascular Prevention, Argentine Society of Cardiology, Azcue´naga 980, C1115AAD Buenos Aires, Argentina
Adv Ther
INTRODUCTION Psoriasis is a systemic inflammatory disorder that involves complex pathogenic interactions between the innate and adaptive immune systems, affecting approximately 2% of the population [1]. Several important diseases occur more often in patients with psoriasis than expected based on their respective prevalence in the general population. Individuals with psoriasis have an increased risk of developing other chronic health diseases such as psoriatic arthritis, metabolic synd
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