Quercetin reduces tendon adhesion in rat through suppression of oxidative stress
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(2020) 21:608
RESEARCH ARTICLE
Open Access
Quercetin reduces tendon adhesion in rat through suppression of oxidative stress Yuan Liang1†, Keteng Xu1†, Pei Zhang2, Jiale Zhang1, Pengtao Chen1, Jinshan He1, Yongchao Fang1, Yuelai Zhou1, Jingcheng Wang1* and Jianzhong Bai3*
Abstract Background: Tendon adhesion is one of the most common clinical problems, which poses a considerable challenge to orthopedics doctors. Quercetin (QUE) as a popular drug at present, it has various biological functions, including anti-inflammatory, anti-ischemic, anti-peroxidation, and antioxidant. The purpose of this study was to investigate the effect of quercetin on tendon adhesion and whether quercetin can inhibit oxidative stress. Method: Thirty-six rats were randomly divided into three groups, including control group, low QUE (50 mg/kg/day) group, and high QUE (100 mg/kg/day) group. After 1 week, the levels of SOD, MDA and GPx were measured. The degree of tendon adhesion was assessed by macroscopic evaluation and histological evaluation. After 4 weeks. Besides, the pharmacological toxicity of quercetin to main organs were evaluated by histological analysis. Results: The extent of superoxide dismutase (SOD) and glutathione peroxidase (GPx) of tendon tissue in high QUE group was significantly higher than those of low QUE group and control group. And the extent of malondialdehyde (MDA) of tendon tissue in high QUE group was significantly lower than that of low QUE group and control group. By macroscopic evaluation and histological analysis, the extent of tendon adhesion in high QUE group was lower than low QUE group and control group. However, there were no significant changes of the major organs through histological analysis. Conclusions: Quercetin may be a good and safe strategy in preventing tendon adhesion. But further clinical research is needed before its recommendation in the prevention and treatment of tendon adhesion. Keywords: Quercetin, Tendon adhesions, Oxidative stress
Background Tendon adhesion is a critical clinical issue characterized by the limitation of tendon gliding, which poses a considerable challenge to orthopedic doctors [1, 2]. Two pathways are considered to participate in tendon repair. The intrinsic repair pathway involves the internal repair * Correspondence: [email protected]; [email protected] † Yuan Liang and Keteng Xu contributed equally to this work. 1 Department of Orthopedics, Clinical Medical College of Yangzhou University, Subei People’s Hospital, Nantong West Road 98, Yangzhou 225001, China 3 Department of Orthopedics, The Second Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China Full list of author information is available at the end of the article
function of tenocytes, the extrinsic repair process involves the invasion of cells from the outside of tendon and finally promotes the formation of adhesion [3, 4]. As the pathophysiological mechanism of tendon adhesion is not clear, the prevention and treatment of tendon adhesion is still facing challenges. Many methods have be
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