Recent clinical relevance of mono-genital colonization/infection by Ureaplasma parvum
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ORIGINAL ARTICLE
Recent clinical relevance of mono-genital colonization/infection by Ureaplasma parvum Víctor Siles-Guerrero 1 & Inmaculada Cardona-Benavides 2 & Carmen Liébana-Martos 3 & Fernando Vázquez-Alonso 4 & Manuela Expósito-Ruiz 5 & José María Navarro-Marí 6 & José Gutiérrez-Fernández 1,6 Received: 7 April 2020 / Accepted: 12 May 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Ureaplasma parvum is the most prevalent genital mycoplasma in women of childbearing age. There is debate around the relevance of its presence in male or female genitals for disease development and as a cofactor. The objective of this study was to determine the prevalence of colonization/infection by U. parvum and its possible relationship with reproductive tract infections. We retrospectively analyzed the presence of U. parvum in patients referred by specialist clinicians for suspicion of genitourinary tract infection. U. parvum was detected in 23.8% of samples, significantly more frequently in females (39.9%) than in males (6%). Among the males, U. parvum was found alone in 68.4% of episodes, with Ct < 30. Among the females, U. parvum was detected in 88.6% of cases, with Ct < 30, including 22 cases with premature rupture of membranes and 6 cases with threat of preterm labor. Co-infection was significantly more frequent in females (62.6%) than in males (31.6%). Given the high prevalence of U. parvum as sole isolate in males and females with genitourinary symptoms, it should be considered in the diagnosis and treatment of genital infections, although its pathogenic role in some diseases has not been fully elucidated. Keywords Genital infection . Ureaplasma parvum . Emerging infection
Background Mycoplasma spp. and Ureaplasma spp. belong to the Mollicutes class, microorganisms mainly characterized by the absence of a cell wall. Globally, they are known as genital mycoplasmas because of the associated clinical symptoms [1]. Ureaplasma urealyticum was first isolated in 1954, 17 years after the isolation of Mycoplasma hominis [2]. Other species
were subsequently differentiated with the advance of molecular biology techniques, including Mycoplasma genitalium and Ureaplasma parvum. The species U. urealyticum was first considered to contain two closely related “Biovars,” composed of 14 individual serovars based on inhibition by polyclonal rabbit serum, which were eventually separated into two separate species; confusingly, however, one of them retained the original name for the entire species [3].
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10096-020-03928-2) contains supplementary material, which is available to authorized users. * José Gutiérrez-Fernández [email protected] 1
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Department of Microbiology, School of Medicine, University of Granada-Instituto de Investigación Biosanitaria de Granada.ibs, Granada, Spain Department of Obstetrics and Gynecology, University Hospital Virgen de las Nieves– Instituto de Investigación Biosanitaria de Granada, ibs Grana
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