Renal tumor in developing countries: 142 cases from a single institution at Shanghai, China
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Renal tumor in developing countries: 142 cases from a single institution at Shanghai, China Ci Pan, Jiao-Yang Cai, Min Xu, Qi-Dong Ye, Min Zhou, Min-Zhi Yin, Yu-Min Zhong, Jing Chen, Shu-Hong Shen, Jing-Yan Tang Shanghai, China
Original article
Background: The clinical management of children with renal tumors including Wilms' tumor, clear cell sarcoma, rhabdoid tumor and other renal tumors in our center was designed according to the National Wilms' Tumor Study Group protocols. Methods: A total of 142 consecutive patients who had been diagnosed as having renal tumors at Shanghai Children's Medical Center were reviewed retrospectively in the period of December 1998 and September 2012. Diagnosis and treatment were decided by a multidisciplinary team including oncologists, surgeons, pathologists and sub-specialized radiologists. Results: The median age of the patients at the time of diagnosis was 27 months. The tumor stages of the patients were as follows: stage I 24.6%, stage II 23.2%, stage III 32.3%, stage IV 14.1%, and stage V 5.6%. Favorable histology was diagnosed in 80.3%, anaplasia in 4.2%, clear cell sarcoma in 9.8%, rhabdoid tumor in 4.9%, and other renal tumors in 0.7% of the patients. The eventfree and overall 5-year survival rates were 80% and 83%, respectively. Tumor relapse and progress was seen in 25 patients (17.6%). The median relapse time was 6 months (range: 2-37 months). Seven relapsing patients were retreated and four of them got second complete remission (three in stage II, one in stage I). Conclusion: A multi-disciplinary team work model is feasible in developing countries, and the renal tumors
Author Affiliations: Department of Hematology/Oncology (Pan C, Cai JY, Ye QD, Zhou M, Chen J, Shen SH, Tang JY), Department of Surgery (Xu M), Department of Pathology (Yin MZ) and Department of Radiology (Zhong YM), Shanghai Children's Medical Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China Corresponding Author: Jing-Yan Tang, MD, PhD, Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Tel: +86-2138626297; Fax: +86-21-58756539; Email: [email protected]) doi: 10.1007/s12519-015-0041-3
©Children's Hospital, Zhejiang University School of Medicine, China and Springer-Verlag Berlin Heidelberg 2015. All rights reserved.
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protocols basically from developed countries are safe in developing countries. World J Pediatr 2015;11(4):326-330 Key words: China; developing country; multi-disciplinary team; renal tumors
Introduction
R
enal tumors are among the most common malignant solid tumors in children, accounting for 5%-6% of all malignant childhood tumors, with Wilms' tumor (WT) being the most common renal malignancy.[1] The refinement of multimodal therapy, which can include surgery, chemotherapy, and radiation therapy, has remarkably improved the outcome of children with renal tumors, with an overall survival rates of 90% in developed countries.[2,3] The treatment of WT is one of the gr
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