Response to discrepancies in publications related to HMB-FA and ATP supplementation
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LETTER TO THE EDITOR
Open Access
Response to discrepancies in publications related to HMB-FA and ATP supplementation Jacob M Wilson Abstract Gentles and Phillips have submitted questions regarding three recent papers investigating ATP, HMB and the combination. The questions pertaining to the homogeneity of subjects’ characteristics between the three different published papers, and why there appears to be differences in the number of subjects in placebo groups across studies. This response addresses each of these issues and demonstrates that there are no discrepancies between papers but rather a misunderstanding of the papers previously published. Keywords: Hypertrophy, Training adaptations, Muscle growth, Strength Dear Dr. Xu Lin, Liang Sun and Associate Editors, Recently, Gentles and Phillips [1] wrote a communication requesting further explanations regarding our recent publications on ATP [2], HMB-FA [3] and coingestion of ATP and HMB-FA [4] on training adaptations, resulting from the same study with the clinical trial identifier: NCT01508338. We acknowledge that the authors have invested a great deal of time following our work on multiple platforms, and our reexamination only serves to further our understanding of the significance of these studies. In their effort to better understand our research, Gentles and Phillips [1] have submitted questions pertaining to the homogeneity of subjects’ characteristics between the three different published papers, and why there appears to be differences in the number of subjects in placebo groups across studies [2–4]. Our response addresses each of these issues and demonstrates that there are no discrepancies between papers but rather a misunderstanding of the papers previously published. Gentles and Phillips [1] question the homogeneity between papers, providing a table showing that subject characteristics for Wilson et al. [2] and Wilson et al. [3] are even identical. The table by Gentles and Phillips is incorrect. The correct participant characteristics in Wilson et al. [2] are as follows: age 23.4 ± 0.7 with 1-RM Correspondence: [email protected] The Applied Science & Performance Institute, Tampa, United States
of 1.71 ± 0.04, 1.34 ± 0.03 and 2.05 ± 0.04 times body weight for squat, bench press, and deadlift, respectively. We are uncertain as to where the numbers presented by Gentles and Phillips came from in their Table 1. We have provided the corrected Table 1 below. The values in the corrected table add a degree of heterogeneity which may reasonably be expected, but are still quite homogenous. This was accomplished by the randomization procedure. We arranged the subjects by strength, and then performed the randomization. Gentles and Phillips also question the supplement protocol for the placebo group, allowing for the use of the same control group for all three publications from the same study. Subjects received three times per day a gel pack consisting of 1 g of HMB-FA, or a matching placebo gel pack; and once per day a capsule either containing 400 mg per day o
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