Septicemia from Lactobacillus rhamnosus GG , from a Probiotic Enriched Yogurt, in a Patient with Autologous Stem Cell Tr
- PDF / 480,479 Bytes
- 4 Pages / 595.276 x 790.866 pts Page_size
- 37 Downloads / 180 Views
Septicemia from Lactobacillus rhamnosus GG, from a Probiotic Enriched Yogurt, in a Patient with Autologous Stem Cell Transplantation Satoshi Koyama 1,2 & Hiroyuki Fujita 1,3 & Takeshi Shimosato 4 & Aki Kamijo 5 & Yasufumi Ishiyama 1,2 & Eri Yamamoto 1,6 & Yoshimi Ishii 1,6 & Yukako Hattori 1,7 & Maki Hagihara 1 & Etsuko Yamazaki 1,8 & Naoto Tomita 1,9 & Hideaki Nakajima 1 & On behalf of the Yokohama Cooperative Study Group for Hematology (YACHT)
# Springer Science+Business Media, LLC, part of Springer Nature 2018
Abstract Probiotic-rich foods are consumed without much restriction. We report here, a case of septic shock caused by yogurt derived Lactobacillus species in a 54-year-old male patient with acute promyelocytic leukemia, in second complete remission, and who was an autologous stem cell transplantation recipient. He received high dose chemotherapy and autologous peripheral blood stem cell transplantation. He ingested commercially available probiotic-enriched yogurt because of severe diarrhea. One week later, he developed septic shock, and the pathogen was determined by strain-specific PCR analysis as Lactobacillus rhamnosus GG (ATCC 53103), which was found to be identical with the strain in the yogurt he consumed. Thus, because even low virulent Lactobacilli in the probiotic products can be pathogenic in the compromised hosts, ingestion of such products should be considered with caution in neutropenic patients with severe diarrhea, such as stem cell transplantation recipients. Keywords Lactobacillus . Probiotic yogurt, bacteremia . Leukemia . Stem cell transplantation
Introduction Lactobacillus (L.) species, gram negative bacteria, usually constitute the normal human bowel microflora. These organisms are generally recognized as low-virulence, and some strains of these bacteria are the main components in probiotic ‘foods’, which were found to enhance the function of the immune system [1, 2]. A randomized control study in children showed that the consumption of probiotic microbes reduces the incidence of acute infectious, nosocomial and antibioticassociated diarrhea in various pediatric settings [3]. However, * Hiroyuki Fujita [email protected] 1
Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan
some of these organisms can also be pathogenic, resulting in serious clinical infectious diseases including bacteremia, infective endocarditis, intra-abdominal abscess, and pulmonary infections [4–9]. We report here a case of sepsis caused by L. species in an autologous stem cell transplantation recipient after ingesting probiotic-enriched yogurt. Molecular analysis identified the responsible pathogen to have originated from the yogurt. We would like to alert to exercise caution while taking probiotic products such as yogurt during neutropenia with severe diarrhea. 5
Department of Transfusion, Yokohama City University Hospital, Yokohama, Japan
6
Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan
7
Departme
Data Loading...
